Navegando por Assunto "Metabolismo"

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Acesso aberto (Open Access)
Circulating early biomarkers of atherogenesis in participants of the Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease
(Universidade Federal do Pará, 2016-12) PITITTO, Bianca de Almeida; RIBEIRO FILHO, Fernando de Souza Flexa; BARRETO, Sandhi Maria; DUNCAN, Bruce Bartholow; SCHMIDT, Maria Inês; LOTUFO, Paulo Andrade; BENSENOR, Isabela Judith Martins; VIVOLO, Sandra Roberta Gouvea Ferreira
Our aim was to describe the distribution of selected biomarkers according to age and sex, adjusted for HOMA-IR and adiposity, in a subset of middle-aged individuals of Brazilian Longitudinal Study of Adult Health-ELSA without diabetes mellitus or CVD. Subjects and methods: This crosssectional study was conducted in 998 participants of the ELSA-Brasil without diabetes and/or cardiovascular disease. In addition to the traditional risk factors, several biomarkers concentrations were compared according to sex, age groups (35-44; 45-54 yrs) and HOMA-IR tertiles. Linear regression was used to examine independent associations of sex and age with selected novel biomarkers, adjusted for body adiposity and HOMA-IR. Results: Fifty-five percent were women. Men had higher mean values of body mass index, waist circumference, blood pressure, plasma glucose, HOMA-IR, worse lipid profile and higher E-selectin and lower leptin concentrations than women; while women had higher levels of HDL-cholesterol and leptin than men. Mean values of waist circumference, systolic BP, plasma glucose and apolipoprotein B (Apo B) increased with age in both sexes. Leptin and E-selectin concentrations increased across HOMA-IR tertiles. Independent associations of Apo B with age were found only in male sex, while of leptin with body mass index and HOMA-IR, and of E-selectin with HOMA-IR in both sexes. Conclusions: In conclusion, our data indicate age, sex, adiposity and, consequently, insulin resistance, influence circulating levels of Apo B, leptin and E-selectin, suggesting that those aspects should be taken into consideration when assessing these parameters for research or clinical purposes in individuals at relatively low cardiometabolic risk.
Acesso aberto (Open Access)
Diagnóstico das deficiências de macro e micro minerais em búfalas (Bubalus bubalis) provenientes da Ilha de Marajó, Estado do Pará
(Universidade Federal do Pará, 2014-06-30) OLIVEIRA, Carlos Magno Chaves; BARBOSA NETO, José Diomedes; http://lattes.cnpq.br/1516707357889557
This study aimed to evaluate in buffaloes of the Marajó Island serum concentrations and phosphorus in bones, the percentage of ashes and the specific density of the bones, the levels of copper, cobalt, selenium, zinc and iron before and after selective mineral supplementation. For this study, 14 crossbred buffaloes of Murrah and Mediterranean aged between 18 and 36 months were used. The average values of phosphorus, before supplementation, were 5, 68 mg/dl ± 1.18 in serum and 16.53% ± 0.53 in the bones. The percentage of ashes in bones was 59.95% ± 1.96 and the specific bone density was 1,52 g/cm3 ± 0.32, which demonstrates a phosphorus deficiency in animals raised on the island of Marajó. The average copper values were 7.75 ± 1.73 ppm, the cobalt ± 0.17 0.40 ppm, the zinc of 88.01 ± 35.03 ppm, the 0.22 ppm selenium and iron ± 0.12 1395.72 ± 764.74 ppm. These results indicate a deficiency of copper, zinc and selenium, cobalt and appropriate values of excess iron in the liver. After supplementation for a period of seven months the phosphorus values were 6.61 mg / dl in serum ± 0.87 and 16.90 ± 0.56% in the bones. The percentage of ash was 60.30% ± 0.95 and the specific bone density was 1.71 g/cm3 ± 0.21. These values characterize a significant increase in the concentrations of P in blood serum, in the percentage of P in the ashes and on specific bone density (P < 0.05), however there wasn't a significant increase in the percentage of ash. The average increase in the values of P in the bones and the ashes did not reach heights of normality, however 28.6% of the animals had normal serum P values, 50% had normal values of P in the ashes and 64.3% of the animals had specific normal bone density. There was no response to supplementation in relation to the percentage of ash. Regarding micro minerals, after supplementation values were 205.41 ± 80.54 ppm for copper, 0.40 ± 0.22 ppm for cobalt, 75.71 ± 11.74 ppm for zinc, 1.30 ppm ± 1.34 for selenium and 826.48 ± 394.76 ppm for iron, which shows a significant increase (P <0.05) concentrations of copper and selenium and a significant decrease in the amounts of iron (P <0, 05). There was no response to supplementation in relation to the percentage of ashes. Regarding micro minerals, after supplementation values were 205.41 ± 80.54 ppm for copper, 0.40 ± 0.22 ppm for cobalt, 75.71 ± 11.74 ppm for zinc, 1.30 ppm ± 1.34 for selenium and 826.48 ± 394.76 ppm for iron, which shows a significant increase (P <0.05) concentrations of copper and selenium and a significant decrease in the amounts of iron (P <0, 05). There was no recovery of zinc and cobalt concentrations which remained within the normal range. Failure to increased concentrations of zinc in the liver after supplementation may have occurred because of the high concentrations of calcium in Brachiaria brizantha cv Marandu used in animal nutrition.
Acesso aberto (Open Access)
Planejamento, Síntese, Avaliação das Propriedades Teóricas de orto-Regioisômeros Substituídos do Paracetamol
(Universidade Federal do Pará, 2018-12-28) MORAIS, Roberto Barbosa de; BORGES, Rosivaldo dos Santos; http://lattes.cnpq.br/4783661132100859; https://orcid.org/0000-0003-4072-7573
Paracetamol is a clinically proven analgesic and antipyretic, which promotes analgesia by elevating the pain threshold and antipyretic through action in the hypothalamic center that regulates the temperature. Currently paracetamol is one of the medicines that is available in all the countries of the world in places related to health and can be acquired without prescription. Considered one of the most widely used drugs in the world as it is cheap and easy to access, it can also be used from birth to the elderly. Like non-steroidal anti-inflammatory drugs (NSAIDs) paracetamol is able to inhibit the synthesis of prostaglandins from arachidonic acid under specific conditions by inhibiting cyclooxygenase (COX). Although it is considered safe at therapeutic doses, Paracetamol has a toxicity attributed to one of its metabolic intermediates called N-acetyl-p-imine-benzoquinone (NAPQI), produced through enzymes present in cytochrome P450 (CYPE21). Thus, the objective of this present work is to plan, synthesize and evaluate possible antinociceptive and antipyretic activities of paracetamol analogues, ortacetamol and its derivatives in order to obtain a less toxic derivative. The calculations of electronic properties such as higher energy occupied molecular orbital (HOMO), lower energy unoccupied molecular orbital (LUMO), ionization potential (PI), phenolic bond dissociation energy (BDEOH) and spin densities were performed using the Gaussview and Gaussian 2009 packages. The values of the average values of BDENH, among others, are those that are observed with the quality of a heating cycle for the high speed with the possibility of a chelation defined by a hydrogen bond of the amide with the phenoxyl radical. Given the results it is possible that BDENH energy compounds may be less potent than hindering the action of CYP on oxidation to form toxic intermediates. A proposed chlorinated derivative was proposed and synthesized. It is in biological evaluation phase. Orthacetamol was more potent antioxidant than paracetamol. Experimental results are in aggrement with theoretical values. We conclude that ortcetamol may be a potentially safer bioactive candidate than paracetamol.