Navegando por Assunto "Neuralgia"

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Influence of tramadol on functional recovery of acute spinal cord injury in rats
(Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2018-12) CHAVES, Rosa Helena de Figueiredo; SOUZA, Celice Cordeiro de; FURLANETO, Ismari Perini; TEIXEIRA, Renan Kleber Costa; OLIVEIRA, Carolina Pinheiro de; RODRIGUES, Emanuelle de Matos; SANTOS, Daniel Arthur Santos dos; SILVA, Renata Cunha; PENHA, Nelson Elias Abrahão da; LIMA, Ana Rita de
Purpose: To evaluate the influence tramadol on functional recovery of acute spinal cord injury in rats. Methods: Ten rats were divided into two groups (n = 5). All animals were submitted by a aminectomy and spinal cord injury at eighth thoracic vertebra. In control group, the rats didn’t receive any analgesic. In tramadol group, the rats received tramadol 4mg/Kg at 12/12h until 5 days by subcutaneous. Animals were following by fourteen days. Was evaluated the Basso, Beattie, Bresnahan scale (locomotor evaluation) and Rat Grimace Scale (pain evaluation) at four periods. Results: There no difference between the groups in locomotor evaluation in all periods evaluated (p>0.05) and in both groups there was a partial recover of function. The tramadol group show a lower pain levels at the first, third and seventh postoperatively days when comparing to the control group. Conclusion: The tramadol as an analgesic agent don’t influence on functional recovery of acute spinal cord injury in rats.