Navegando por Assunto "Nociceptividade"

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Acesso aberto (Open Access)
Antinociceptive effects of the essential oil of Mentha x villosa leaf and its major constituent piperitenone oxide in mice
(2009-07) SOUSA, Pergentino José da Cunha; LINARD, Cybelle Facanha Barreto Medeiros; BATISTA, Danilo de Azevedo; OLIVEIRA, Ariclécio Cunha de; SOUZA, Andrelina Noronha Coelho de; CARDOSO, José Henrique Leal
Mentha x villosa Huds (Labiatae) is an aromatic herb widely used in folk medicine. Since the essential oil of the herb has many pharmacological activities, including antispasmodic effects, we determined whether the oil and its major constituent, piperitenone oxide (PO), have antinociceptive activity. The essential oil of M. x villosa (EOMV) and PO administered orally at 200 mg/kg (vehicle: 0.1% Tween 80 in water) significantly reduced the writhings induced by acetic acid from control values of 59.5 ± 3.1 s (N = 10) to 31.9 ± 2.8 s (N = 10) and 23.8 ± 3.4 s (N = 10), respectively. When administered at 100 and 200 mg/kg, EOMV reduced the paw licking time for the second phase of the formalin test from the control value of 20.6 ± 2.1 s (N = 13) to 5.3 ± 2.2 s (N = 12) and 2.7 ± 1.2 s (N = 18), respectively. At 100 and 200 mg/kg, PO reduced this second phase to 8.3 ± 2.7 s (N = 12) and 3.0 ± 1.2 s (N = 10), respectively. This effect of EOMV and PO was not reversed by naloxone. EOMV and PO had no significant effect on the first phase of the formalin test. As evaluated by the hot-plate and tail immersion test, EOMV and PO, at doses up to 200 mg/kg, showed no analgesic activity. These results show that EOMV and PO have antinociceptive activity and suggest that this effect is probably an indirect anti-inflammatory effect, which does not involve the central nervous system.
Acesso aberto (Open Access)
Avaliação neurocomportamental, antinociceptiva e antioxidante do extrato hidroalcoólico de Eupatorium ayapana Vent (Asteraceae)
(Universidade Federal do Pará, 2012-03-30) MELO, Ademar Soares; SOUSA, Pergentino José da Cunha; http://lattes.cnpq.br/9909053957915090; MAIA, Cristiane do Socorro Ferraz; http://lattes.cnpq.br/4835820645258101
The Eupatorium ayapana Vent., Family Asteraceae, popularly known as japana is used in infusions, decoctions, baths and tea, with sedative, febrifuge, stimulant and tonic, also used to combat insomnia, headache, sore throat, diarrhea, etc.., commonly used by the Amazonian population. This study evaluated the effect of different doses of hydroalcoholic extract of Eupatorium ayapana Vent (EHAEA) on the behavior of Wistar rats, aged 2 months. We used eight groups of rats (n = 7-10) that were divided into control, standard drug action anxiolytic (diazepam), standard drug action antidepressant (fluoxetine) and five doses of the extract (100, 200, 400, 600, 800 mg/kg) which were solubilized with 1% tween 80. The administration of the extract was performed acutely by gavage. In oral toxicity test, it was found that the extract is not toxic. The behavioral tests were used: the open field, the elevated plus maze (EPM) and forced swimming. After the behavioral tests was performed to collect blood in the retro-orbital plexus of rats to assess the levels of oxidative stress such as Total Antioxidant Capacity, MDA and NO, and also the total antioxidant EHAEA. The results obtained in the open field test showed anxiolytic-like activity, a result confirmed in the LCE. In the forced swimming test, the EHAEA showed antidepressant action of any kind. In tests of nociception, which was used mice occurred in antinociceptive abdominal writhing test in doses of 200, 400, 600 and 800 mg/kg. In evaluating the biochemical oxidation, it was observed that there was no oxidative damage in the treated groups EHAEA, NO levels were unchanged at doses of 200, 400 and 600 mg total antioxidant capacity was shown to be increased. With these results, this paper aims to contribute to future work, have seen, are few studies in the behavioral area, in nociception and oxidative stress in this plant species, and that further studies may enhance the use of the extract in folk medicine japana.