Navegando por Assunto "Osteoporose"

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Alterações endócrinas e metabólicas em pacientes HIV positivos com lipodistrofia
(Universidade Federal do Pará, 2007-11-30) YAMANO, Ernesto Yoshihiro Seki; LIBONATI, Rosana Maria Feio; http://lattes.cnpq.br/3818175484709618
Lipodystrophy is one of the complications of highly active antiretroviral therapies (HAART). This study evaluates the metabolic and endocrine changing in patients with lipodystrophy. Forty patients were evaluated and classified as lipoatrophy, lipohypertrophy and mixed syndrome. We analyzed insulin resistance for HOMA-IR (Homeostasis Model Assesment Insulin Resistance), fasten glucose and OGTT, urea, creatinine, TSH, Free T4, cortisol, DHEA, ratio cortisol/DHEA, prolactin, testosterone (in male), FSH, LH and estradiol (in female), total cholesterol, LDL-c, HDL-c, uric acid. Anthropometrics measures (Weight, height, body mass index, waist, hip and skin folds thickness), ultrasonographic exams for evaluate hepatic steatosis and measure of bone density. The isolated lipohipertrophy occurred only in female (p<0,05). The mean of age was similar in the groups, without changing in the distribution by age group. Dyslipidemia occurred in all groups after HAART (lipodystrophy mixed, 100%, lipohypertrophy, 80% and lipoatrophy, 70%). Antropometric data showed waist increased in the female with lipohypertrophy (98+ 13,4) and decreased in female with lipoatrophy (76,8 + 6,1). Patients with lipoatrophy have been eutrophic (82,4%) and patients with lipohypertrophy have overweight or obesity (60%). Male was associated with osteoporosis (p < 0,05). We found elevated prevalence of the dyslipidemia (85%) and metabolic syndrome (37,5%) in all groups. The metabolic syndrome was associated with lipohypertrophy. No significant changes were found in the thyroid, cortisol, cortisol/DHEA ratio, testosterone, FSH, LH and prolactina. Conclusions: Female is associated with isolated lipohypertrophy, metabolic syndrome and insulin resistance. Male is related with Osteopenia and osteoporosis. Hepatic steatosis were common, but is not influenced for a type of lipodystrophy. Hormonal changing were unusual events in lipodystrophy.
Acesso aberto (Open Access)
Avaliação das anormalidades do metabolismo mineral ósseo em pacientes portadores de lipodistrofia e HIV positivos
(Universidade Federal do Pará, 2012-03-21) OLIVEIRA, Danielle Lima de; LIBONATI, Rosana Maria Feio; http://lattes.cnpq.br/3818175484709618
The advances in antirretroviral therapy (HAART) markedly suppressed viral activity and increased longevity of those living with HIV / AIDS, however, a variety of metabolic abnormalities related to treatment was reported after the introduction of HAART combined among these complications, changes in bone mineral density arouse special attention, not only for its long-term implications, but also by the conflicting data available in the literature. OBJECTIVES: to evaluate changes in bone mineral density, and correlate them with sex, age, body mass index body, types of lipodystrophy, laboratory levels of serum calcium, parathyroid hormone and vitamin D and hormonal profile. METHODS: in this cross-sectional study 77 HIV patients with lipodystrophy syndrome treated with highly active antirretroviral therapy (HAART), and enrolled in the clinic lipodystrophy of the João de Barros Barreto University Hospital. The clinical examination of patients involved the measurement of weight, height and waist circumference. Laboratory tests performed included measurement of serum calcium, vitamin D, parathyroid hormone, estradiol, testosterone.Patients were divided into three groups according to the form of lipodystrophy: mixed, atrophic and hypertrophic. RESULTS: most patients were male, and the predominant form of lipodystrophy was mixed form. The mean time of infection after HIV diagnosis was 10.98 ± 6.03 years. The prevalence of osteopenia was 61.03% and osteoporosis was 25.97%. The male patients presented more frequently osteoporosis in femoral neck and the female patients in the lumbar spine. Osteoporosis in the lumbar spine was more prevalent in the mixed form of lipodystrophy and the femoral neck and shown to be similar between the atrophic and mixed forms of lipodystrophy. And the frequency of osteoporosis was present in all sequences of age in males and in females only after 50 years. CONCLUSIONS: the prevalence of osteoporosis increases with age in females. There was no association between BMD and the form of lipodystrophy.
Acesso aberto (Open Access)
Cartilha educativa sobre saúde óssea para pessoas que vivem com Diabetes Mellitus
(Universidade Federal do Pará, 2024-06-21) KHALED, Isabel Jane Campos Lobato; QUEIROZ, Natércia Neves Marques; http://lattes.cnpq.br/5359261920325026
Diabetes Mellitus has been linked to poorer bone health, leading to a higher risk of fractures in people living with diabetes. DM affects bone health in various ways. To prevent and manage bone problems in patients, some strategies need to be adopted, such as strict glycemic control, a diet with adequate intake of calcium and vitamin D, and physical exercises with an emphasis on strengthening activities. The educational approach values popular experiences and promotes the individual's autonomy in self-care. The aim of this study was to develop an educational booklet with the purpose of generating knowledge for the individual, using a descriptive-exploratory methodology to develop a lightweight health technology. The material was produced using easily understandable language and objective images.