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Navegando por Assunto "Pain"

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    Dor Musculoesquelética na Coluna Vertebral em Crianças e Adolescentes: uma análise de rede
    (Universidade Federal do Pará, 2024-08-27) GOMES, Marcella Veronnica Pereira; MAGALHÃES, Maurício Oliveira; http://lattes.cnpq.br/7766377002832983; https://orcid.org/0000-0002-7857-021X
    Introduction: Musculoskeletal pain is common in children and adolescents, with prevalence ranging from 4% to 40%. Back pain-related symptoms rank 5th in terms of years lived with disability among children aged 10 to 19 years, affecting approximately 2.443 million people. Additionally, it is associated with high healthcare costs and can lead to persistent pain in adulthood. Objective: To analyze the relationship between musculoskeletal pain in the spine in children and adolescents through a network approach. Methods: The study population consists of children and adolescents of both genders, who are regularly enrolled in elementary and high school. Children and adolescents of both genders aged between 10 and 16 years were included. The Back Pain and Body Posture Assessment Instrument (BackPEI-CA) and the Instrutherm pressure algometer, model DD-500, were used to assess pain intensity and threshold, respectively. Data were tabulated, and JASP was used for statistical analysis. A network analysis was conducted to investigate descriptive relationships between individual and contextual factors with self-reported symptoms of back and neck pain. Results: 185 participants were included in the analysis. The network analysis observed that the variable 'Lower Back Pain' was negatively correlated with 'Family Pain History' (-0.14) and positively correlated with 'Sex' (0.19) and 'Neck Pain' (0.12). The 'Sitting Position When Using Cell Phone/ tablet' showed a negative correlation with 'Neck Pain' (-0.19). A negative correlation was observed between 'Sex' and 'Physical Activity Outside School'. Centrality metrics indicated that 'Age' (betweenness = 1.420) and 'Sex' (betweenness = 1.278) had the highest betweenness values. Conclusion: The study concludes that sex is a significant variable in back pain among children and adolescents, with a higher prevalence among girls, possibly due to sexual maturation and lower levels of physical activity compared to boys, who are more active. Additionally, the pain is influenced by poor posture while writing at school and using electronic devices. However, the results should be interpreted with caution due to the limitations of the analysis.
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    ItemAcesso aberto (Open Access)
    Influence of tramadol on functional recovery of acute spinal cord injury in rats
    (Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2018-12) CHAVES, Rosa Helena de Figueiredo; SOUZA, Celice Cordeiro de; FURLANETO, Ismari Perini; TEIXEIRA, Renan Kleber Costa; OLIVEIRA, Carolina Pinheiro de; RODRIGUES, Emanuelle de Matos; SANTOS, Daniel Arthur Santos dos; SILVA, Renata Cunha; PENHA, Nelson Elias Abrahão da; LIMA, Ana Rita de
    Purpose: To evaluate the influence tramadol on functional recovery of acute spinal cord injury in rats. Methods: Ten rats were divided into two groups (n = 5). All animals were submitted by a aminectomy and spinal cord injury at eighth thoracic vertebra. In control group, the rats didn’t receive any analgesic. In tramadol group, the rats received tramadol 4mg/Kg at 12/12h until 5 days by subcutaneous. Animals were following by fourteen days. Was evaluated the Basso, Beattie, Bresnahan scale (locomotor evaluation) and Rat Grimace Scale (pain evaluation) at four periods. Results: There no difference between the groups in locomotor evaluation in all periods evaluated (p>0.05) and in both groups there was a partial recover of function. The tramadol group show a lower pain levels at the first, third and seventh postoperatively days when comparing to the control group. Conclusion: The tramadol as an analgesic agent don’t influence on functional recovery of acute spinal cord injury in rats.
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    Investigação da toxicidade oral aguda e propriedades farmacológicas de uma espécie do gênero Cassytha
    (Universidade Federal do Pará, 2019-05-15) BARROS, Mayra Arouck; FONTES JÚNIOR, Enéas de Andrade; http://lattes.cnpq.br/7056265073849866; https://orcid.org/ 0000-0002-6186-9581
    Plants have been present in human culture since its inception, being used for several purposes, including for the treatment of diseases. This practice has been handed down from generation to generation. The evolution of knowledge, however, demands broader approaches on plant species with therapeutic potential, in order to ensure safety and validate its traditional use. Cassytha filiformis, a species of the genus Cassytha, is used in folk medicine to treat cancer, trypanosomiasis, kidney disease and gonorrhea. Among its proven activities, the antiplatelet, vascular relaxing, antioxidant, cytotoxic, antihypertensive, hepatoprotective, antiepileptic, diuretic and alpha-adrenergic receptor antagonist effects stand out. Among its secondary metabolites, alkaloids have been identified for therapeutic benefit. To date, however, there are no studies that support the safety of its therapeutic application or that explore possible anti-inflammatory properties as the basis for its therapeutic actions. Acute oral toxicity was assessed according to OECD 425. Starting from an administration of 2000 mg / kg (v.o) of extract in rats, the hippocratic signs of toxicity, spontaneous locomotor activity, weight gain, water and food consumption, as well as relative body weight and hematological patterns at the end of the period. The antinociceptive activity was evaluated in mice, using the acetic acid induced writhing test and the formalin test (CEUA nº 1050140817). The cutoff dose of the extract did not promote hipocratic signs of toxicity or death. There were also no changes in feed and water consumption or weight gain patterns. The evaluation of the relative weight of organs (liver, kidneys, stomach and heart) and hemogram showed equivalent standards between treated and control animals. Cas01 also did not impair the locomotor activity of the animals. Cas01 was shown to have no influence on the contortions induced by acetic acid, nor did it promote significant alterations on formalin-induced biphasic nociception. These findings demonstrate for the first time that Cas 01 is a xenobiotic of low acute oral toxicity. They also demonstrate that their therapeutic actions do not involve nociceptive or inflammatory mechanisms.
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