Navegando por Assunto "Parkinson's disease"

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Os efeitos da atividade física baseada em movimentos de dança no movimento, funções executivas, episódios depressivos e qualidade de vida de pessoas com doença de Parkinson
(Universidade Federal do Pará, 2022-06-21) DUARTE, Juliana dos Santos; KREJCOVÁ, Lane Viana; http://lattes.cnpq.br/2604693973864638; BAHIA, Carlomagno Pacheco; http://lattes.cnpq.br/0910507988777644; https://orcid.org/0000-0003-3794-4710
Parkinson's disease is considered the second most frequent neurodegenerative disease in the world and is characterized by being chronic and progressive. Motor symptoms are understood, but non-motor symptoms may be present and appear at different temporal stages of the disease. Although pharmacological treatments are important to alleviate PD symptoms, they are still limited and most often trigger side effects. Therefore, therapeutic approaches that complement the pharmacological approach are increasingly being investigated to assess their possible beneficial effects on symptomatology and disease progression. Physical activity based on dance movements is emerging as a therapeutic approach to a range of PD symptoms as it is a multidimensional activity that requires rhythmic synchronization and more neuromuscular functions. To evaluate the effects of physical activity based on dance movements on movement, executive functions, depressive episodes and quality of life in individuals diagnosed with PD. 13 individuals with PD (8♀ 5♂), aged 65.9 ± 6.5 years (mean ± SD), Hoehn & Yahr stages I to III, MDS-UPDRS 67.62 ± 20.83 (mean ± SD) performed two weekly sessions (50 min/session) of physical activity based on dance movements for six months. The assessment protocols were performed pre and post-intervention, applying the POMA test to assess movement, the FAB test to assess executive function and subdomains, the MADRS test to assess depressive episodes, the PDQ-39 questionnaire to assess the perception of quality of life and, finally, the MDS-UPDRS scale to assess the severity of PD. Student's t test was used to compare pre- and post-intervention results of physical activity based on dance movements. The significance level was 95% (p < 0.05). We observed significant improvement in balance and gait by the POMA test, t (12) = 2.283, p = 0.0207. Executive function by the FAB test, t (12) = 2.840, p = 0.0074, abstract reasoning and inhibitory control by the subdomains of the FAB Conceptualization test, t (12) = 2.941, p = 0.0062, and Inhibitory Control, t (12) = 2.920, p = 0.0064, showed significant improvements between the pre- and post-intervention periods of physical activity based on dance movements. Depressive episodes assessed by the MADRS test significantly reduced, t (12) = 2.264, p = 0.0214, and the perception of quality of life by the PDQ-39 had a significant increase after physical activity based on dance movements, t (12) = 4.239, p = 0.0006. We did not observe significant changes in PD severity. Physical activity based on dance movements has shown to have attenuating potential in movement, executive functions, depressive episodes and quality of life in PD, and may be effective in future rehabilitation. The characteristic elements of physical activity based on dance movements such as rhythmic synchronization, more cognitive-motor integration and social skills may have contributed to the results obtained in this study.
Acesso aberto (Open Access)
Modelo experimental para indução de hemiparkinsonismo por 6-hidroxidopamina em primatas sapajus apella e avaliação das alterações motoras
(Universidade Federal do Pará, 2019-06-09) LEAL, Leon Claudio Pinheiro; KREJČOVÁ, Lane Viana; http://lattes.cnpq.br/2604693973864638; https://orcid.org/0000-0001-8016-5283; BAHIA, Carlomagno Pacheco; http://lattes.cnpq.br/0910507988777644; https://orcid.org/0000-0003-3794-4710
Parkinson's disease is currently the second most common neurodegenerative disease in the world, with a high incidence in North and South America and Europe, for more than 50 years we have not seen any revolutionary treatment for the disease and many aspects of its neuropathology that still remain without a concrete enlightenment, in this feeling the experimental model in primates approaches the human reality are invaluable value for the development of new therapies and elucidation on mechanisms related to the disease. The 6-hydroxydopamine model in primates is a model that mimics some motor symptoms characteristic of PD. The present study aimed to develop a protocol for the induction of HemiParkinsonism in Sapajus apella primates. Three Sapajus Apella monkeys, all adult males, were submitted to daily conditioning sessions using the positive reinforcement clicker technique for primate chair positioning. Concurrently, the staircase and Brinkman tray motor tests were performed to determine laterality by the manual preference and dominance attributes. After this period, two 6-OHDA induction protocols were performed, the first protocol was injected into 10 sites in the nucleus striatum and the second protocol was injected into 10 sites in the nigrostriatal pathways, one week after the injections were performed twelve weeks of clinical analysis . All animals learned the input and positioning behaviors in the chair in a minimum of 30 sessions using pure positive reinforcement. The results of the staircase test demonstrated that the animals presented laterality consistent with the assignments of manual preference and dominance. The Brinkman test, specifically, presented lower sensitivity for determination of the same attributes, despite being the most commonly used test. Clinical analysis revealed that the second induction protocol had more motor symptoms characteristic of PD. Induction by 6-OHDA in the nigrostriatal pathways has been shown to be a good induction method for treatment studies and for a better understanding of the disease.
Acesso aberto (Open Access)
Parkinson pai d’égua: protocolo de danças amazônicas sobre os parâmetros não motores e motores em pessoas com Parkinson
(Universidade Federal do Pará, 2024-06-25) COSTA, Carla Luana Alves; HAAS, Aline Nogueira; http://lattes.cnpq.br/6600425096998622; https://orcid.org/0000-0003-4583-0668; MONTEIRO, Elren Passos; http://lattes.cnpq.br/0920248966438368; https://orcid.org/0000-0001-7757-6620
Introduction: In Parkinson's disease, dopaminergic neurons degenerate. Dance has been shown to be a non-pharmacological intervention for PD symptoms. However, the benefits are mostly assessed in motor symptoms. However, it is believed that the characteristics of Amazonian dances can be a stimulus for improving and/or maintaining the motor and non motor symptoms of PD. However, no studies with Amazonian dances in people with Parkinson's were found Methods: The aim of the study was to analyze the responses of Amazonian dances and cultural manifestations on the non-motor symptoms of global cognition, mood, depressive symptoms and quality of life in people with Parkinson's in the Amazon region and to evaluate an intra-group control period of Health Education and compare it with the effects of dances. This is a longitudinal study. Participants will be people with Parkinson's of both sexes, stage 1 to 4 on the Hoehn and Yahr scale. The volunteers took part in evaluations before and after the Health Education period, Protocol and follow up. The data was collected and tabulated in Excel, and analyzed using SPSS software version 27.0. We used descriptive statistics to characterize the sample, and Generalized Estimating Equations to compare moments, groups and subtypes of PD. In addition, the effect size was calculated using Edges' d. Results When analyzing depressive symptoms, significant differences were found for the Group factor (p=0.049) and the ES intervention (7.00±1.15; 6.50±0.96). When we analyzed mood states by domains, for the Anger domain, the Group (p= 0.35) and Time (p= 0.66) factors did not show significant values. For global cognitive function, significant differences were found for the Group factor (p<0.001).Conclusion: The present study shows benefits of the Health Education Program of the Amazonian Dances and Cultural Manifestations protocol for PcP in non-motor symptoms of depressive symptoms in both interventions. This indicates that Amazonian dances and cultural manifestations can be used with caution for the rehabilitation of non-motor and motor symptoms in people with Parkinson's disease.