Navegando por Assunto "Propranolol"

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Acesso aberto (Open Access)
Hemangiomas extensos da infância tratados com propranolol: relato de dois casos
(2011-06) CAVALEIRO, Luíza Helena dos Santos; VIANA, Fernanda de Oliveira; UNGER, Deborah Aben-Athar; BITTENCOURT, Maraya de Jesus Semblano
Hemangiomas are the most common benign tumors of childhood. They show rapid growth, followed by a regression phase that culminates in the partial or total disappearance of the lesion. Therapeutic options should be evaluated for extensive cases. Systemic glucocorticoids are the therapy of choice; however, there are reports that propranolol offers better and faster results. We report two cases of large volume infantile hemangioma associated with functional limitation and aesthetic disfigurement, treated successfully with propranolol, a drug that comes as a therapeutic option providing satisfactory and maintained results, with few side effects.
Acesso aberto (Open Access)
Obtenção e caracterização de hidrogéis de poliacrilamida-co-metilcelulose como sistemas carreadores de cloridrato de propranolol
(Universidade Federal do Pará, 2011-07-06) ALVES, Taís Vanessa Gabbay; SILVA JÚNIOR, José Otávio Carréra; http://lattes.cnpq.br/4437885351749994; COSTA, Roseane Maria Ribeiro; http://lattes.cnpq.br/0537372052713559
Polymer matrices such as ‖hydrogels‖ are controlled release systems that are being widely used the pharmaceutical industry. In this study, the hydrogels PAAmco-MC were obtained and characterized in order to carry the propranolol, an antihypertensive drug. These hydrogels are composed of two monomers (AAm and MC) and were synthesized by free radical polymerization, being investigated four concentrations of AAm (3.6%, 7.2%, 14.7% and 21.7% w / v). The characterization of the hydrogels was performed through studies of the degree of swelling, zeta potential, FT-IR, SEM, and thermal analysis (TG, DTA, DTG and DSC). The 3.6% hydrogel showed a greater degree of swelling in all analysis media. The zeta potential revealed that all hydrogels remain near the isoelectric point. The infrared absorption spectrum allowed the identification of characteristic bands of both the hydrogel as propranolol. The TG curves of the hydrogels evidenced their degradation in two stages, being observed in the DTG curve a higher mass loss at about 400°C and the DTA and DSC curves have confirmed the three endothermic events. On the other hand, propranolol has a single stage of degradation and its melting peak was at 163.4°C. Photomicrographs have revealed arrangement of the three-dimensional network of hydrogels. In the study of in vitro release kinetics of the release of propranolol from the hydrogel matrix was approximately 80% of drug within 424 hours, showing a bimodal model. This work showed that the PAAmco-MC hydrogel is a great promising for application in drug carrier systems.