Navegando por Assunto "Quinina"
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Item Acesso aberto (Open Access) Correlação entre as concentrações sérica e eritrocitária de quinina no estado de equilíbrio em pacientes com malária por Plasmodium falciparum não complicada(Universidade Federal do Pará, 2007) GUIMARÃES, Erika Rodrigues; VIEIRA, José Luiz Fernandes; http://lattes.cnpq.br/2739079559531098The correlation between the serum and red blood cells concentrations of quinine was studied in children and adults with falciparum malaria uncomplicated in Cachoeira of the Piriá, in the State of Pará. The patients had received the oral scheme of quinine (3 days) + doxycyclina (5 days) + primaquine (6º day). Quinine concentration in the serum and the red blood cells samples was measured by High Performance Liquid Chromatography in the third day of treatment. The average of the serum concentration of the quinine in children with uncomplicated falciparum malaria was of 0,723 ± 0,6 μg/mL, and 0,537 ± 0,38 μg/mL for the red blood cells. And the relationship between the serum and red blood cells concentration was 1,89 ± 1,25 μg/mL, had not difference statistical significant between those concentrations. The average of the serum concentration of adult individuals was of 1,27 ± 1,12 μg/mL, and 0,63 ± 0,48 μg/mL for the red blood cells. The relationship between those concentration was of 2,27 ± 1,06 μg/mL. The results had shown that it did not have significant statistical difference between the averages of the relation of quinine levels in the serum and the red blood cells of the children and the adults.Item Acesso aberto (Open Access) Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil(2008-10) VIEIRA, José Luiz Fernandes; BORGES, Larissa Maria Guimarães; NASCIMENTO, Margareth Tavares Silva; GOMES, Andreza de Lourdes SouzaWe examined the plasmatic concentrations of quinine in patients with uncomplicated falciparum malaria in an endemic area of the Amazon region in Brazil in a prospective clinical trial, in which a standard three-day course of oral quinine plus doxycycline was used. We measured the quinine in the plasma samples on days 0 and 3by high performance liquid chromatography. The mean concentration of quinine was 6.04 ±2.21 µg/mL in male patients and 5.98 ±1.95 µg/mL in female patients. No significant differences in quinine concentration were observed between these two groups. All samples collected before starting treatment were negative for quinine. This information could help in the development of strategies for the rational use of antimalarial drugs in Brazil.Item Acesso aberto (Open Access) Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy(2009-04) VIEIRA, José Luiz Fernandes; GOMES, Andreza de Lourdes Souza; BORGES, Larissa Maria Guimarães; GUIMARÃES, Erika RodriguesWe determined the relationship between plasma and red blood cell concentrations of quinine in children with uncomplicated falciparum malaria from an endemic area of Amazonian region. Quinine was determined by high performance liquid chromatography with ultraviolet detection. In the steady state the ratio between plasma and red blood cell quinine concentration was 1.89 ± 1.25 ranging from 1.05 to 2.34. This result demonstrated that quinine do not concentrate in red blood cell of Brazilian children and characterize the absence of interracial difference in this relationship.