Navegando por Assunto "Rabies virus"

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Acesso aberto (Open Access)
Imunopatologia experimental do vírus da raiva, com as variantes antigênicas 2 e 3
(Universidade Federal do Pará, 2015-06-02) CASSEB, Livia Medeiros Neves; VASCONCELOS, Pedro Fernando da Costa; http://lattes.cnpq.br/0973550817356564
The rabies is considered a zoonosis due have as host, reservoirs and transmitters the domestic or wild mammals. It´s characterized in acute disease caused by rabies virus (RABV) that affects the central nervous system (CNS) characterized by encephalitis with fatal prognosis in almost all cases, in any mammalian species. The aim of this study was to describe pathological findings and immunopathology of different strains of rabies virus in the tissues of the central nervous system, checking cellular and humoral immune response during experimental infection of Mus musculus mice. The animals were inoculated with two antigenic variants of RABV (VAg2 and VAg3), by different routes of infection, and a control group. The animals were observed for development of clinical signs and symptoms, collected and euthanized following a kinetic. The tissues were fixed in formaldehyde 10%, embedded in paraffin, stained with hematoxylin-eosin for histopathological analysis and with specific antibodies for immunohistochemical to characterize and quantify in situ distribution of the antigen and the inflammatory response. RABV antigens were found in the CNS in a diffuse way, but mainly in neurons. It was observed suppression of CD4+ lymphocytes, with increase of CD8+ lymphocytes. It was observed significant apoptosis with glial cell death and an increase of proinflammatory cytokines (TNF-α, IFN-γ, IL-6, IL-1β and IL-8), anti-inflammatory (TGF-β and IL-4) and iNOS in both antigenic variants of RABV, but without observation of a TH17 profile. The analyses enable the characterization of rabies as meningoencephalitis, since it affects the meningeal, perivascular and intraparenchymal microenvironments. And the inflammatory process was observed even in the presence of inclusion bodies, but with less intensity.
Acesso aberto (Open Access)
Raiva humana e transmissão do vírus rábico por morcegos: o que sabe e como se informa a população de um município sob risco na Amazônia brasileira
(Universidade Federal do Pará, 2019-07-01) ANDRADE, Etiene Monteiro de; BEZERRA, Isis Abel; http://lattes.cnpq.br/3274919406647242
The objective of this study was to verify what the population of Curuçá, a municipality in the Amazon of Pará, in which bat attacks are second in reports of aggression by animals, knows about the transmission, prevention and risks of rabies, especially that transmitted bats, as well as identifying the means of communication used by the population to inform themselves about the disease and news in general. A cross-sectional observational study was carried out, with a sample of 377 city dwellers, randomly selected by means of a proportional stratified sampling, considering the census sectors of Curuçá as strata. These subjects answered a semi-structured questionnaire to assess what they knew about rabies and the means used to obtain this information. As a result, it was found that the majority of respondents (72.9%) stated that they know what rabies is, although they do not know how to indicate aspects such as reservoirs, forms of transmission and symptoms, in addition to not presenting self-care practices for rabies. prevention. It was also found that the bat is the second most present animal in reports of aggressions (24.6%) and that the majority of respondents (67.9%) were unaware of the outbreaks in the state in 2004 and 2005. It was concluded with this study that the knowledge of the population of Curuçá about rabies is limited, obtained mainly in their own circle of coexistence, through personal contacts and as for the mass media, a preference was found to obtain information by means that do not require reading, such as television and radio. This work points out what content needs to be accessible to this population and the means of communication that would be most effective in this socio-geographical and cultural context.