Navegando por Assunto "Vatairea guianensis"

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Acesso aberto (Open Access)
Avaliação biológica dos extratos obtidos das sementes de Vatairea guianensis (Aublet).
(Universidade Federal do Pará, 2011-03-28) SILVA, Cléia Tereza Lamarão da; SOUSA, Pergentino José da Cunha; http://lattes.cnpq.br/9909053957915090; CARVALHO, José Carlos Tavares; http://lattes.cnpq.br/4251174810000113
Medicinal plants are widely used and culturally in the amazon to treat various diseases.Much of these plants has not been scientifically invesgated especially on the aspects related to biological activitie.The species selected in this work is Vatairea guianensis, used in traditional medicine to treat skin infections such as cutaneous mycoses. This study evaluated the antibacterial activity in vitro of hydroethanolic extract, hexane, chloroform and methanol Vatairea guianensis seeds by microdilution method for obtaining the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Gram positive (Staphylococcus aureus and Enterecoccus faecalis) and Gram negative bacteria (Pseudomonas aeruginosa and Salmonella sp). The study also evaluated the healing activity on open wounds in rats by topical aplication of the hydroethanolic extract, represented by G1 positive control (fibrinase), G2 negative control (saline) and experimental groups( G3 dose 500mg/kg, G4 250mg/kg,G5 100mg/kg) for seven days and the acute oral toxicity. Histological analysis of the healing process was evaluated by means of conventional technique including color HE and Picrossirius for observation of the inflammatory reaction histomorphological characteristics and descriptive analysis of collagen deposition, respectively. All extracts showed antibacterial activity against all tested microorganisms with an MIC ranging from 3,12μg/mL to 50μg/mL and MBC values 6,25μg/mL to 100μg/mL. In histological analysis, the hidroethanolic extract decreased the intensity of inflammation in the groups G1 and G3, stimulates the synthesis of collagen type III em G1, G3 and G4 and increased collagen synthesis in G2 and G5. The experiment with the hydroethanolic extract obtained from seeds of Vatairea guianensis appeared to slow down the healing process effect by preventing the formation of hypertrophic scar, suggesting a modulatory effect by extract. The acute toxicity evaluation in mouse revealed that the hydroethanlic extract showed low toxicity by the oral proceedings.
Acesso aberto (Open Access)
New isoflavones from the leaves of Vatairea guianensis Aublé
(2013-11) SOUZA, Ronilson Freitas de; MARINHO, Victor Hugo de Souza; SILVA, Geilson Alcantara da; COSTA JUNIOR, Livio Martins; SILVA, Joyce Kelly do Rosário da; BASTOS, Gilmara de Nazareth Tavares; ARRUDA, Alberto Cardoso; SILVA, Milton Nascimento da; ARRUDA, Mara Silvia Pinheiro
Four isoflavones were isolated from Vatairea guianensis Aublé leaves and identified as 5,3'-dihydroxy-4'-methoxy-2",2"-dimethylpyrano-(5",6":8,7)-isoflavone ( 1: ), 5,7-dihydroxy-3',4'-methylenedioxy-8-prenyl-isoflavone ( 2: ), 5,3'-dihydroxy-4'-methoxy-7-O-β-glucopyranoside-8-prenyl-isoflavone ( 3: ) and derrone ( 4: ) together with five triterpenes identified in mixture, lupeol, α-amyrin, β-amyrin, germanicol and betulinic acid. Substances 1: 3: are novel natural products, although 1: and 2: have been cited as synthetic products. However, all these compounds are first reported from this species. Their chemical structures were elucidated based on their 1D and 2D nuclear magnetic resonance (NMR) data and high resolution mass spectrometry. The ethanol extract from the leaves and 1: 3: were evaluated for their potential in scavenging DPPH• (2,2-diphenyl-1-picrylhydrazylradical) and the results showed that the extract presented high activity (IC50 = 6.2 ± 0.4 µg mL-1), while the isolated compounds showed low antioxidant power (IC50 ≥ 29.5 ± 2.5 µg mL-1) when compared to Trolox (IC50 = 4.5 ± 0.4 µg mL-1).
Acesso aberto (Open Access)
A New Prenylisoflavone from the Antifungal Extract of Leaves of Vatairea guianensis Aubl.
(Universidade Federal do Pará, 2017-06) SOUZA, Ronilson Freitas de; SILVA, Geilson Alcantara da; ARRUDA, Alberto Cardoso; SILVA, Milton Nascimento da; SANTOS, Alberdan Silva; GRISÓLIA, Daniella Paternostro de Araújo; SILVA, Moisés Batista da; ARRUDA, Mara Silvia Pinheiro
A new compound, 5,7,3'-trihydroxy-4'-methoxy-8-prenylisoflavone, was isolated from the leaves of Vatairea guianensis Aubl. (Fabaceae), together with two known isoflavones lupiwighteone and 5,7,4'-trihydroxy-3'-methoxy-8-prenylisoflavone. All isolated compounds were characterized based on infrared (IR), UV, 1H and 13C nuclear magnetic resonance (NMR), including 2D NMR analyses and high resolution mass spectrometry. The ethanolic extract from V. guianensis leaves displayed activity against Candida dubliniensis, C. albicans and C. krusei. However, the EtOAc fraction from that extract exhibited more significant activity than the ethanolic extract, showing antifungal activity for all fungi species investigated. The major compound 5,7,3'-trihydroxy-4'-methoxy-8-prenylisoflavone isolated from that EtOAc fraction was also active against C. parapsilosis and C. dubliniensis.