Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju

dc.creatorVANDERLINDE, Frederico Argollo
dc.creatorROCHA, Fabio Fagundes da
dc.creatorMALVAR, David do Carmo
dc.creatorFERREIRA, Raquel Teixeira
dc.creatorCOSTA, Elson Alves
dc.creatorFLORENTINO, Iziara Ferreira
dc.creatorGUILHON, Giselle Maria Skelding Pinheiro
dc.creatorLIMA, Thereza Christina Monteiro de
dc.date.accessioned2013-06-03T13:13:51Z
dc.date.available2013-06-03T13:13:51Z
dc.date.issued2012-02
dc.description.abstractMikania lindleyana DC., Asteraceae (sucuriju), grows in the Amazon region, where is frequently used to treat pain, inflammatory diseases and scarring. This study was carried out to investigate phytochemical profile accompanied by in vivo antinociceptive and anti-inflammatory screening of n-hexane (HE), dichloromethane (DME) and methanol (ME) extracts obtained from the aerial parts of the plant. The oral administration of ME (0.1, 0.3, 1 g/kg) caused a dose-related reduction (16.2, 42.1 e 70.2%) of acetic acid-induced abdominal writhing while HE and DME (1 g/kg, p.o.) were ineffective. In the hot plate test, ME (300 mg/kg, p.o.) increased the latency of heat stimulus between 30 and 120 min and inhibited the first (45%) and second (60%) phases of nociception in the formalin test. The antinociception induced by ME or positive control fentanyl (150 µg/kg, s.c.) in hot plate and formalin tests was prevented by naloxone (3 mg/kg, s.c.). When submitted to the carrageenan-induced peritonitis test, ME (0.5, 1.0, 2.0 g/kg, p.o.) impaired leukocyte migration into the peritoneal cavity by 46.8, 59.4 and 64.8% respectively, while positive control dexamethasone (2 mg/kg, s.c.), inhibited leukocyte migration by 71.1%. These results indicate that the antinociception obtained after oral administration of methanol extract of M. lindleyana involves anti-inflammatory mechanisms accompanied with opioid-like activity which could explain the use of the specie for pain and inflammatory diseases.pt_BR
dc.identifier.citationVANDERLINDE, Frederico A., et al. Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju. Revista Brasileira de Farmacognosia, Curitiba, v. 22, n. 1, p. 150-156, jan./fev. 2012, Epub 14 out. 2011. Disponível em: <http://www.scielo.br/pdf/rbfar/v22n1/aop18511.pdf>. Acesso em: 29 maio 2013. <http://dx.doi.org/10.1590/S0102-695X2011005000190>.pt_BR
dc.identifier.issn0102-695X
dc.identifier.urihttps://repositorio.ufpa.br/handle/2011/3944
dc.language.isoengpt_BR
dc.rightsAcesso Aberto
dc.subjectFitoterapiapt_BR
dc.subjectAgentes antiinflamatóriospt_BR
dc.subjectAnalgésicospt_BR
dc.subjectMikania lindleyanapt_BR
dc.subjectAsteraceaept_BR
dc.subjectSucurijupt_BR
dc.subjectBelém - PApt_BR
dc.subjectPará - Estadopt_BR
dc.subjectAmazônia brasileirapt_BR
dc.titleAnti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucurijupt_BR
dc.typeArtigo de Periódicopt_BR

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