Methemoglobinemia and dapsone levels in patients with leprosy

dc.creatorVIEIRA, José Luiz Fernandes
dc.creatorRIVERA, Juan Gonzalo Bardález
dc.creatorMARTINS, Ana de Nazaré Silva
dc.creatorSILVA, Jorge Pereira da
dc.creatorSALGADO, Claudio Guedes
dc.date.accessioned2011-12-14T16:47:21Z
dc.date.available2011-12-14T16:47:21Z
dc.date.issued2010-06
dc.description.abstractThe objective of this work was to determine the methemoglobinemia and correlate with dapsone levels in multibacillary leprosy patients under leprosy multi-drug therapy. Thirty patients with laboratory and clinical diagnosis of multibacillary leprosy were enrolled. Dapsone was analyzed by high performance liquid chromatography and methemoglobinemia by spectrophotometry. The mean dapsone concentrations in male was 1.42 g/mL and in female was 2.42 g/mL. The mean methemoglobin levels in male was 3.09 µg/mL; 191%, and in female was 2.84 ± 1.67%. No correlations were seen between dapsone levels and methemoglobin in male and female patients. Our results demonstrated that the dosage of dapsone in leprosy treatment does not promote a significant methemoglobinemia.pt_BR
dc.identifier.citationVIEIRA, Jose Luiz Fernandes et al. Methemoglobinemia and dapsone levels in patients with leprosy. Brazilian Journal of Infectious Diseases, Salvador, v. 14, n. 3, p.319-321, maio/jun. 2010. Disponível em: <http://www.scielo.br/pdf/bjid/v14n3/v14n3a22.pdf>. Acesso em: 14 dez. 2011. http://dx.doi.org/10.1590/S1413-86702010000300022.pt_BR
dc.identifier.issn1413-8670
dc.identifier.urihttp://www.repositorio.ufpa.br:8080/jspui/handle/2011/2422
dc.language.isoengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMetemoglobinapt_BR
dc.subjectDapsonapt_BR
dc.subjectHanseníasept_BR
dc.subjectDoenças infecciosas
dc.titleMethemoglobinemia and dapsone levels in patients with leprosypt_BR
dc.typeArtigo de Periódicopt_BR

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