The prion protein and New World primate phylogeny

dc.creatorSCHNEIDER, Igor
dc.creatorSCHNEIDER, Horacio
dc.creatorSCHNEIDER, Maria Paula Cruz
dc.creatorSILVA, Artur Luiz da Costa da
dc.date.accessioned2011-05-10T17:07:00Z
dc.date.available2011-05-10T17:07:00Z
dc.date.issued2004
dc.description.abstractThe PrPC prion protein contains 250 amino acids with some variation among species and is expressed in several cell types. PrPC is converted to PrPSc by a post-translational process in which it acquires amino acid sequences of three-dimensional conformation of -sheets. Variations in the prion protein gene were observed among 16 genera of New World primates (Platyrrhini), and resulted in amino acid substitutions when compared with the human sequence. Seven substitutions not yet described in the literature were found: W  R at position 31 in Cebuella, T  A at position 95 in Cacajao and Chiropotes, N S at position 100 in Brachyteles, L  Q at position 130 in Leontopithecus (in the sequence responsible for generating the -sheet 1), D  E at position 144 in Lagothrix (in the sequence responsible for the -helix 1), D G at position 147 in Saguinus (also located in the -helix 1 region), and M  I at position 232 in Alouatta. The phylogenetic trees generated by parsimony, neighbor-joining and Bayesian analyses strongly support the monophyletic status of the platyrrhines, but did not resolve relationships among families. However, the results do corroborate previous findings, which indicate that the three platyrrhine families radiated rapidly from an ancient split.pt_BR
dc.identifier.citationSCHNEIDER, Igor et al. The prion protein and New World primate phylogeny. Genetics and Molecular Biology, online, v. 27, n. 4, p. 505-510, 2004. DOI: http://dx.doi.org/10.1590/S1415-4757200400040000. Disponível em: http://www.repositorio.ufpa.br/jspui/handle/2011/2177. Acesso em:.pt_BR
dc.identifier.doi10.1590/S1415-4757200400040000
dc.identifier.issn1415-4757
dc.identifier.urihttp://www.repositorio.ufpa.br/jspui/handle/2011/2177
dc.language.isoengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectFilogenia molecularpt_BR
dc.subjectProteína prionpt_BR
dc.subjectPrimatapt_BR
dc.titleThe prion protein and New World primate phylogenypt_BR
dc.typeArtigo de Periódicopt_BR

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