Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer

dc.creatorBURBANO, Rommel Mario Rodriguéz
dc.creatorMEDEIROS, Arnaldo Correia de
dc.creatorMELLO, Adriano Azevedo de
dc.creatorLEMOS, José Alexandre Rodrigues de
dc.creatorBAHIA, Marcelo de Oliveira
dc.creatorCASARTELLI, Cacilda
dc.date.accessioned2014-06-30T12:54:33Z
dc.date.available2014-06-30T12:54:33Z
dc.date.issued2000-11
dc.description.abstractBreast cancer in families with germ line mutations in the TP53 gene has been described in the medical literature. Mutation screening for susceptibility genes should allow effective prophylactic and preventive measures. Using single-strand conformational polymorphism, we screened for mutations in exons 5, 6, 7 and 8 of gene TP53 in the peripheral blood of 8 young non-affected members (17 to 36 years old) of families with a history of breast cancer. Studies of this type on young patients (mean age, 25 years) are very rare in the literature. The identification of these mutations would contribute to genetic counseling of members of families with predisposition to breast cancer. The results obtained did not show any polymorphism indicating mutation. In our sample, the familial tumorigenesis is probably related to other gene etiologies.pt_BR
dc.identifier.citationBURBANO, R.R. et al. Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 33, n. 11, p. 1325-1328, nov. 2000. Disponível em: <http://www.scielo.br/pdf/bjmbr/v33n11/3793m.pdf>. Acesso em: 24 fev. 2014. <http://dx.doi.org/10.1590/S0100-879X2000001100010>.pt_BR
dc.identifier.issn1414-431X
dc.identifier.urihttps://repositorio.ufpa.br/handle/2011/5180
dc.language.isoengpt_BR
dc.rightsAcesso Aberto
dc.subjectTP53pt_BR
dc.subjectNeoplasias da mamapt_BR
dc.subjectCâncer de mamapt_BR
dc.subjectHistória familiarpt_BR
dc.subjectMutaçãopt_BR
dc.subjectGene TP53pt_BR
dc.titleInvestigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancerpt_BR
dc.typeArtigo de Periódicopt_BR

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