Environmental influences on antibody-enhanced dengue disease outcomes

dc.creatorDINIZ, Daniel Guerreiro
dc.creatorFÔRO, César Augusto Raiol
dc.creatorTURIEL, Maíra Catherine Pereira
dc.creatorSÓSTHENES, Márcia Consentino Kronka
dc.creatorDEMACHKI, Samia
dc.creatorGOMES, Giovanni Freitas
dc.creatorREGO, Carla M Damasceno
dc.creatorMAGALHÃES, Marina Cutrim
dc.creatorPINHO, Brunno Gomes
dc.creatorRAMOS, Juliana Pastana
dc.creatorCASSEB, Samir Mansour Moraes
dc.creatorBRITO, Maysa de Vasconcelos
dc.creatorSILVA, Eliana Vieira Pinto da
dc.creatorNUNES, Márcio Roberto Teixeira
dc.creatorDINIZ JUNIOR, José Antônio Picanço
dc.creatorCUNNINGHAM, Colm
dc.creatorPERRY, Victor Hugh
dc.creatorVASCONCELOS, Pedro Fernando da Costa
dc.creatorDINIZ, Cristovam Wanderley Picanço
dc.date.accessioned2014-11-27T15:10:27Z
dc.date.available2014-11-27T15:10:27Z
dc.date.issued2012-12
dc.description.abstractBecause an enriched environment (EE) enhances T-cell activity and T-lymphocytes contribute to immunopathogenesis during heterologous dengue virus (DENV) infections, we hypothesised that an EE increases dengue severity. To compare single serotype (SS) and antibody-enhanced disease (AED) infections regimens, serial intraperitoneal were performed with DENV3 (genotype III) infected brain homogenate or anti-DENV2 hyperimmune serum followed 24 h later by DENV3 (genotype III) infected brain homogenate. Compared AED for which significant differences were detected between the EE and impoverished environmental (IE) groups (Kaplan-Meyer log-rank test, p = 0.0025), no significant differences were detected between the SS experimental groups (Kaplan-Meyer log-rank test, p = 0.089). Survival curves from EE and IE animals infected with the AED regimen were extended after corticoid injection and this effect was greater in the EE than in the IE group (Kaplan-Meyer log-rank test, p = 0.0162). Under the AED regimen the EE group showed more intense clinical signs than the IE group. Dyspnoea, tremor, hunched posture, ruffled fur, immobility, pre-terminal paralysis, shock and death were associated with dominant T-lymphocytic hyperplasia and presence of viral antigens in the liver and lungs. We propose that the increased expansion of these memory T-cells and serotype cross-reactive antibodies facilitates the infection of these cells by DENV and that these events correlate with disease severity in an EE.pt_BR
dc.identifier.citationDINIZ, Daniel Guerreiro et al. Environmental influences on antibody-enhanced dengue disease outcomes. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 8, p. 1021-1029, dez. 2012. Disponível em: <http://www.scielo.br/pdf/mioc/v107n8/10.pdf>. Acesso em: 25 nov. 2014. <http://dx.doi.org/10.1590/S0074-02762012000800010>.pt_BR
dc.identifier.issn0074-0276
dc.identifier.urihttps://repositorio.ufpa.br/handle/2011/6119
dc.language.isoengpt_BR
dc.rightsAcesso Aberto
dc.subjectDoenças infecciosaspt_BR
dc.subjectDenguept_BR
dc.subjectInfluência ambientalpt_BR
dc.subjectLinfócitos Tpt_BR
dc.titleEnvironmental influences on antibody-enhanced dengue disease outcomespt_BR
dc.typeArtigo de Periódicopt_BR

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