Association of killer cell immunoglobulin-like receptor polymorphisms with chronic hepatitis C and responses to therapy in Brazil
dc.creator | VASCONCELOS, Janaina Mota de | |
dc.creator | MÓIA, Lizomar de Jesus Maués Pereira | |
dc.creator | AMARAL, Ivanete do Socorro Abraçado | |
dc.creator | MIRANDA, Esther Castello Branco Mello | |
dc.creator | TAKESHITA, Louise Yukari | |
dc.creator | OLIVEIRA, Layanna Freitas de | |
dc.creator | MENDES, Lilian de Araújo Melo | |
dc.creator | SASTRE, Danuta | |
dc.creator | TAMEGÃO-LOPES, Bruna Pedroso | |
dc.creator | PEDROZA, Larysse Santa Rosa de Aquino | |
dc.creator | SANTOS, Sidney Emanuel Batista dos | |
dc.creator | SOARES, Manoel do Carmo Pereira | |
dc.creator | ARAÚJO, Marialva Tereza Ferreira de | |
dc.creator | BANDEIRA, Camila Lucas | |
dc.creator | SILVA, Adriana Maria Paixão de Sousa da | |
dc.creator | MEDEIROS, Zilene Lameira de | |
dc.creator | SENA, Leonardo dos Santos | |
dc.creator | DEMACHKI, Sâmia | |
dc.creator | SANTOS, Eduardo José Melo dos | |
dc.date.accessioned | 2013-12-11T12:35:26Z | |
dc.date.available | 2013-12-11T12:35:26Z | |
dc.date.issued | 2013 | |
dc.description.abstract | Soroprevalence for Hepatitis C virus is reported as 2.12% in Northern Brazil, with about 50% of the patients exhibiting a sustained virological response (SVR). Aiming to associate polymorphisms in Killer Cell Immunoglobulin-like Receptors (KIR) with chronic hepatitis C and therapy responses we investigated 125 chronic patients and 345 controls. Additionally, 48 ancestry markers were genotyped to control for population stratification. The frequency of the KIR2DL2 and KIR2DL2+HLA-CAsp80 gene and ligand was higher in chronic infected patients than in controls (p < 0.0009, OR = 3.4; p = 0.001, OR = 3.45). In fact, KIR2DL3 is a weaker inhibitor of NK activity than KIR2DL2, which could explain the association of KIR2DL2 with chronic infection. Moreover, KIR2DS2 and KIR2DS2+HLA-CAsp80 (p < 0.0001, OR = 2.51; p = 0.0084, OR = 2.62) and KIR2DS3 (p < 0.0001; OR = 2.57) were associated with chronic infection, independently from KIR2DL2. No differences in ancestry composition were observed between control and patients, even with respect to therapy response groups. The allelic profile KIR2DL2/KIR2DS2/KIR2DS3 was associated with the chronic hepatitis C (p < 0.0001; OR = 3). Furthermore, the patients also showed a higher mean number of activating genes and a lower frequency of the homozygous AA profile, which is likely secondary to the association with non-AA and/or activating genes. In addition, the KIR2DS5 allele was associated with SVR (p = 0.0261; OR = 0.184).The ancestry analysis of samples ruled out any effects of population substructuring and did not evidence interethnic differences in therapy response, as suggested in previous studies. | pt_BR |
dc.identifier.citation | VASCONCELOS, Janaina Mota de et al. Association of killer cell immunoglobulin-like receptor polymorphisms with chronic hepatitis C and responses to therapy in Brazil. Genetics and Molecular Biology, São Paulo, v. 36, n. 1, p. 22-27, 2013. Disponível em: <http://www.scielo.br/pdf/gmb/v36n1/a04v36n1.pdf>. Acesso em: 10 dez. 2013. <http://dx.doi.org/10.1590/S1415-47572013000100004>. | pt_BR |
dc.identifier.issn | 1415-4757 | |
dc.identifier.uri | https://repositorio.ufpa.br/handle/2011/4515 | |
dc.language.iso | eng | pt_BR |
dc.rights | Acesso Aberto | |
dc.subject | Hepacivirus | pt_BR |
dc.subject | Antígenos HLA-C | pt_BR |
dc.subject | KIR | pt_BR |
dc.subject | Hepatite C | pt_BR |
dc.subject | KIR2DL2 | pt_BR |
dc.title | Association of killer cell immunoglobulin-like receptor polymorphisms with chronic hepatitis C and responses to therapy in Brazil | pt_BR |
dc.type | Artigo de Periódico | pt_BR |