Association of killer cell immunoglobulin-like receptor polymorphisms with chronic hepatitis C and responses to therapy in Brazil

dc.creatorVASCONCELOS, Janaina Mota de
dc.creatorMÓIA, Lizomar de Jesus Maués Pereira
dc.creatorAMARAL, Ivanete do Socorro Abraçado
dc.creatorMIRANDA, Esther Castello Branco Mello
dc.creatorTAKESHITA, Louise Yukari
dc.creatorOLIVEIRA, Layanna Freitas de
dc.creatorMENDES, Lilian de Araújo Melo
dc.creatorSASTRE, Danuta
dc.creatorTAMEGÃO-LOPES, Bruna Pedroso
dc.creatorPEDROZA, Larysse Santa Rosa de Aquino
dc.creatorSANTOS, Sidney Emanuel Batista dos
dc.creatorSOARES, Manoel do Carmo Pereira
dc.creatorARAÚJO, Marialva Tereza Ferreira de
dc.creatorBANDEIRA, Camila Lucas
dc.creatorSILVA, Adriana Maria Paixão de Sousa da
dc.creatorMEDEIROS, Zilene Lameira de
dc.creatorSENA, Leonardo dos Santos
dc.creatorDEMACHKI, Sâmia
dc.creatorSANTOS, Eduardo José Melo dos
dc.date.accessioned2013-12-11T12:35:26Z
dc.date.available2013-12-11T12:35:26Z
dc.date.issued2013
dc.description.abstractSoroprevalence for Hepatitis C virus is reported as 2.12% in Northern Brazil, with about 50% of the patients exhibiting a sustained virological response (SVR). Aiming to associate polymorphisms in Killer Cell Immunoglobulin-like Receptors (KIR) with chronic hepatitis C and therapy responses we investigated 125 chronic patients and 345 controls. Additionally, 48 ancestry markers were genotyped to control for population stratification. The frequency of the KIR2DL2 and KIR2DL2+HLA-CAsp80 gene and ligand was higher in chronic infected patients than in controls (p < 0.0009, OR = 3.4; p = 0.001, OR = 3.45). In fact, KIR2DL3 is a weaker inhibitor of NK activity than KIR2DL2, which could explain the association of KIR2DL2 with chronic infection. Moreover, KIR2DS2 and KIR2DS2+HLA-CAsp80 (p < 0.0001, OR = 2.51; p = 0.0084, OR = 2.62) and KIR2DS3 (p < 0.0001; OR = 2.57) were associated with chronic infection, independently from KIR2DL2. No differences in ancestry composition were observed between control and patients, even with respect to therapy response groups. The allelic profile KIR2DL2/KIR2DS2/KIR2DS3 was associated with the chronic hepatitis C (p < 0.0001; OR = 3). Furthermore, the patients also showed a higher mean number of activating genes and a lower frequency of the homozygous AA profile, which is likely secondary to the association with non-AA and/or activating genes. In addition, the KIR2DS5 allele was associated with SVR (p = 0.0261; OR = 0.184).The ancestry analysis of samples ruled out any effects of population substructuring and did not evidence interethnic differences in therapy response, as suggested in previous studies.pt_BR
dc.identifier.citationVASCONCELOS, Janaina Mota de et al. Association of killer cell immunoglobulin-like receptor polymorphisms with chronic hepatitis C and responses to therapy in Brazil. Genetics and Molecular Biology, São Paulo, v. 36, n. 1, p. 22-27, 2013. Disponível em: <http://www.scielo.br/pdf/gmb/v36n1/a04v36n1.pdf>. Acesso em: 10 dez. 2013. <http://dx.doi.org/10.1590/S1415-47572013000100004>.pt_BR
dc.identifier.issn1415-4757
dc.identifier.urihttps://repositorio.ufpa.br/handle/2011/4515
dc.language.isoengpt_BR
dc.rightsAcesso Aberto
dc.subjectHepaciviruspt_BR
dc.subjectAntígenos HLA-Cpt_BR
dc.subjectKIRpt_BR
dc.subjectHepatite Cpt_BR
dc.subjectKIR2DL2pt_BR
dc.titleAssociation of killer cell immunoglobulin-like receptor polymorphisms with chronic hepatitis C and responses to therapy in Brazilpt_BR
dc.typeArtigo de Periódicopt_BR

Arquivo(s)

Pacote Original

Agora exibindo 1 - 1 de 1
Carregando...
Imagem de Miniatura
Nome:
Artigo_AssociationKillerCell.pdf
Tamanho:
452.5 KB
Formato:
Adobe Portable Document Format

Licença do Pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.66 KB
Formato:
Item-specific license agreed upon to submission
Descrição: