Primary endemic Cryptococcosis gattii by molecular type VGII in the state of Pará, Brazil

dc.creatorSANTOS, Wallace Raimundo Araujo dos
dc.creatorMEYER, Wieland
dc.creatorCOSTA, Solange do Perpétuo Socorro Evangelista
dc.creatorTRILLES, Luciana
dc.creatorNASCIMENTO, José Luiz Martins do
dc.creatorSOUSA, Rita Catarina Medeiros
dc.creatorMORALES, Bernardina Penarrieta
dc.creatorBEZERRA, Cláudia de Carvalho Falci
dc.creatorMACÊDO, Regina Célia Lima de
dc.creatorFERREIRA, Silvana O.
dc.creatorBARBOSA, Gláucia Gonçalves
dc.creatorPEREZ, Mauricio de Andrade
dc.creatorNISHIKAWA, Marília Martins
dc.creatorLAZÉRA, Márcia dos Santos
dc.date.accessioned2011-11-03T15:02:15Z
dc.date.available2011-11-03T15:02:15Z
dc.date.issued2008-12
dc.description.abstractIn order to study the infectious agents causing human disseminated cryptococcosis in the state of Pará, North Brazil, 56 isolates of Cryptococcusspp. (54 isolated from cerebral spinal fluid and two from blood cultures) from 43 cases diagnosed between 2003-2007 were analysed. The species were determined through morphological and physiological tests and genotypes were determined by URA5-RFLP and PCR-fingerprinting (wild-type phage M13). The following species and genotypes were identified: Cryptococcus neoformans VNI (28/56, 50%), Cryptococcus gattii VGII (25/56, 44.64%) and C. gattii VGI (3/56, 5.26%). The genotype VNI occurred in 12 out of 14 HIV-positive adults, whereas the genotype VGII occurred in 11 out of 21 HIV-negative adults (p < 0.02, OR = 6.6 IC95% 0.98-56.0). All patients less than 12 years old were HIV negative and six cases were caused by the VGII genotype, one by the VGI and one by VNI. Therefore, endemic primary mycosis in HIV-negative individuals, including an unexpectedly high number of children, caused by the VGII genotype deserves further study and suggests the need for surveillance on cryptococcal infection in the state of Pará, Eastern Amazon.pt_BR
dc.identifier.citationSANTOS, Wallace Raimundo Araújo dos et al. Primary endemic Cryptococcosis gattii by molecular type VGII in the state of Pará, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 8, p. 813-818, dez. 2008. Disponível em: <http://www.scielo.br/pdf/mioc/v103n8/12.pdf>. Acesso em: 03 nov. 2011. http://dx.doi.org/10.1590/S0074-02762008000800012.pt_BR
dc.identifier.issn0074-0276
dc.identifier.issn1678-8060
dc.identifier.urihttp://www.repositorio.ufpa.br:8080/jspui/handle/2011/2363
dc.language.isoengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCryptococcus gattiipt_BR
dc.subjectVGIIpt_BR
dc.subjectMicosept_BR
dc.subjectCriançaspt_BR
dc.subjectPará - Estadopt_BR
dc.subjectAmazônia brasileirapt_BR
dc.subjectDoenças endêmicaspt_BR
dc.titlePrimary endemic Cryptococcosis gattii by molecular type VGII in the state of Pará, Brazilpt_BR
dc.typeArtigo de Periódicopt_BR

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