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https://repositorio.ufpa.br/jspui/handle/2011/10040
Tipo: | Artigo de Periódico |
Data do documento: | Abr-2015 |
Autor(es): | SÁ, Keyla Santos Guedes de PIRES NETO, Orlando de Souza SANTANA, Bárbara Brasil GOMES, Samara Tatielle Monteiro AMORAS, Ednelza da Silva Graça CONDE, Simone Regina Souza da Silva DEMACHKI, Sâmia AZEVEDO, Vânia Nakauth MACHADO, Luiz Fernando Almeida FEITOSA, Rosimar Neris Martins ISHAK, Marluísa de Oliveira Guimarães ISHAK, Ricardo VALLINOTO, Antonio Carlos Rosário |
Título: | Toll-like receptor 3 gene polymorphisms are not associated with the risk of hepatitis B and hepatitis C virus infection |
Citar como: | SÁ, Keyla Santos Guedes de et al. Toll-like receptor 3 gene polymorphisms are not associated with the risk of hepatitis B and hepatitis C virus infection. Revista da Sociedade Brasileira de Medicina Tropical, Uberaba, v. 48, n. 2, p. 136-142, mar./abr. 2015. Disponível em: <http://repositorio.ufpa.br/jspui/handle/2011/10040>. Acesso em:. |
Abstract: | Introduction: The present study investigated the prevalence of two single-nucleotide polymorphisms (SNPs) in the Toll-like receptor 3 (TLR3) gene in patients infected with hepatitis B virus (HBV) and hepatitis C virus (HCV). Methods: Samples collected from HCV (n = 74) and HBV (n = 35) carriers were subjected to quantitative real-time PCR (qPCR) to detect the presence of the SNPs rs5743305 and rs3775291 in TLR3 and to measure the following biomarkers: alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and prothrombin time (PT). A healthy control group was investigated and consisted of 299 HCV- and HBV-seronegative individuals. Results: No signifi cant differences in allele, genotype and haplotype frequencies were observed between the investigated groups, and no association was observed between the polymorphisms and histopathological results. Nevertheless, genotypes TA/AA (rs5743305) and GG (rs3775291) appear to be associated with higher levels of ALT (p<0.01), AST (p<0.05) and PT (p<0.05). In addition, genotypes TT (rs5743305; p<0.05) and GG (rs3775291; p<0.05) were associated with higher GGT levels. Conclusions: This genetic analysis revealed the absence of an association between the polymorphisms investigated and susceptibility to HBV and HCV infection; however, these polymorphisms might be associated with a greater degree of biliary damage during the course of HCV infection. |
Palavras-chave: | Prevalência Polimofismo de nucleotídeo Hepatite B Hepatite C Infecção por HCV |
CNPq: | CNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA::BIOLOGIA E FISIOLOGIA DOS MICROORGANISMOS::VIROLOGIA |
Título do Periódico: | Revista da Sociedade Brasileira de Medicina Tropical |
ISSN: | 0037-8682 |
País: | Brasil |
Instituição: | Universidade Federal do Pará |
Sigla da Instituição: | UFPA |
Tipo de Acesso: | Acesso Aberto |
Fonte URI: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000200136&lng=pt&nrm=iso |
Identificador DOI: | http://dx.doi.org/10.1590/0037-8682-0008-2015 |
Aparece nas coleções: | Artigos Científicos - ICB |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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Artigo_TolllikeReceptorThree.pdf | 788,92 kB | Adobe PDF | Visualizar/Abrir |
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