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metadata.dc.type: Artigo de Periódico
Issue Date: Aug-2016
metadata.dc.creator: VALLINOTO, Izaura Maria Vieira Cayres
VALLINOTO, Antonio Carlos Rosário
PENA, Giselle Priscila dos Anjos
AZEVEDO, Vânia Nakauth
MACHADO, Luiz Fernando Almeida
ISHAK, Marluísa de Oliveira Guimarães
ISHAK, Ricardo
metadata.dc.description.affiliation: UFPA - Universidade Federal do Pará
Title: JC virus/human immunodeficiency virus 1 co-infection in the Brazilian Amazonian region
Citation: VALLINOTO, Isaura Maria Vieira Cayres et al. JC virus/human immunodeficiency virus 1 co-infection in the Brazilian Amazonian region. Brazilian Journal of infectious Diseases, Salvador, v. 24, n. 4, p. 360-364, jul./ago. 2016. DOI: Disponível em: Acesso em:.
Abstract: JC virus (JCV) is a member of the Polyomaviridae family and is associated with a severe disease known as progressive multifocal leukoencephalopathy, PML, which is progressively increasing in incidence as an opportunistic infection among AIDS patients. The present study aimed to investigate the occurrence of JCV among HIV-1 carriers including their types and molecular subtypes and the possible association with disease.Urine samples from 66 HIV-1 infected subjects were investigated for the presence of the virus by amplifying VP1 (215 bp) and IG (610 bp) regions using the polymerase chain reaction. JCV was detected in 32% of the samples. The results confirmed the occurrence of type B (subtype Af2); in addition, another polyomavirus, BKV, was also detected in 1.5% of samples of the HIV-1 infected subjects. Apparently, there was no significant difference between mono- (HIV-1 only) and co-infected (HIV-1 / JCV) subjects regarding their TCD4 + / TCD8 + lymphocyte counts or HIV-1 viral plasma load. Self admitted seizures, hearing and visual loses were not significantly different between the two groups.
Keywords: JCV
Brazilian Amazon region
Series/Report no.: Brazilian Journal of Infectious Diseases
ISSN: 1678-4391 Brasil
Publisher: Sociedade Brasileira de Infectologia
metadata.dc.publisher.initials: SBI
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICB

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