Use este identificador para citar ou linkar para este item: https://repositorio.ufpa.br/jspui/handle/2011/15723
Tipo: Artigo de Periódico
Data do documento: Jun-2015
Autor(es): ABREU, Vinicius Augusto Carvalho de
ALMEIDA, Sintia Silva de
TIWARI, Sandeep
HASSAN, Syed Shah
MARIANO, Diego César Batista
SILVA, Artur Luiz da Costa da
BAUMBACH, Jan
AZEVEDO, Vasco Ariston de Carvalho
RÖTTGER, Richard
Afiliação do(s) Autor(es): SILVA, A. L. C. Universidade Federal do Pará
Título: CMRegNet–An interspecies reference database for corynebacterial and mycobacterial regulatory networks
Agência de fomento: 
Citar como: ABREU, Vinicius A. C. CMRegNet–An interspecies reference database for corynebacterial and mycobacterial regulatory networks. BMC Genomics, online, v. 16, n. 452, p. 1-10, 2015. DOI: https://doi.org/10.1186/s12864-015-1631-0. Disponível em: https://repositorio.ufpa.br/jspui/handle/2011/15723. Acesso em:.
Abstract: Background: Organisms utilize a multitude of mechanisms for responding to changing environmental conditions, maintaining their functional homeostasis and to overcome stress situations. One of the most important mechanisms is transcriptional gene regulation. In-depth study of the transcriptional gene regulatory network can lead to various practical applications, creating a greater understanding of how organisms control their cellular behavior. Description: In this work, we present a new database, CMRegNet for the gene regulatory networks of Corynebacterium glutamicum ATCC 13032 and Mycobacterium tuberculosis H37Rv. We furthermore transferred the known networks of these model organisms to 18 other non-model but phylogenetically close species (target organisms) of the CMNR group. In comparison to other network transfers, for the first time we utilized two model organisms resulting into a more diverse and complete network of the target organisms. Conclusion: CMRegNet provides easy access to a total of 3,103 known regulations in C. glutamicum ATCC 13032 and M. tuberculosis H37Rv and to 38,940 evolutionary conserved interactions for 18 non-model species of the CMNR group. This makes CMRegNet to date the most comprehensive database of regulatory interactions of CMNR bacteria. The content of CMRegNet is publicly available online via a web interface found at http://lgcm.icb.ufmg.br/cmregnet.
Palavras-chave: Corynebacterium glutamicum
Mycobacterium tuberculosis
Título do Periódico: BMC Genomics
ISSN: 1471-2164
País: Reino Unido
Instituição: BioMed Central Ltd
Tipo de Acesso: Acesso Aberto
Attribution-NonCommercial-NoDerivs 3.0 Brazil
Fonte URI: https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-1631-0#Ack1
Identificador DOI: 10.1186/s12864-015-1631-0
Aparece nas coleções:Artigos Científicos - ICB

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