Use este identificador para citar ou linkar para este item:
https://repositorio.ufpa.br/jspui/handle/2011/15723
Tipo: | Artigo de Periódico |
Data do documento: | Jun-2015 |
Autor(es): | ABREU, Vinicius Augusto Carvalho de ALMEIDA, Sintia Silva de TIWARI, Sandeep HASSAN, Syed Shah MARIANO, Diego César Batista SILVA, Artur Luiz da Costa da BAUMBACH, Jan AZEVEDO, Vasco Ariston de Carvalho RÖTTGER, Richard |
Afiliação do(s) Autor(es): | SILVA, A. L. C. Universidade Federal do Pará |
Título: | CMRegNet–An interspecies reference database for corynebacterial and mycobacterial regulatory networks |
Agência de fomento: | MMCI - Cluster of Excellence for Multimodal Computing and Interaction |
Citar como: | ABREU, Vinicius A. C. CMRegNet–An interspecies reference database for corynebacterial and mycobacterial regulatory networks. BMC Genomics, online, v. 16, n. 452, p. 1-10, 2015. DOI: https://doi.org/10.1186/s12864-015-1631-0. Disponível em: https://repositorio.ufpa.br/jspui/handle/2011/15723. Acesso em:. |
Abstract: | Background: Organisms utilize a multitude of mechanisms for responding to changing environmental conditions, maintaining their functional homeostasis and to overcome stress situations. One of the most important mechanisms is transcriptional gene regulation. In-depth study of the transcriptional gene regulatory network can lead to various practical applications, creating a greater understanding of how organisms control their cellular behavior. Description: In this work, we present a new database, CMRegNet for the gene regulatory networks of Corynebacterium glutamicum ATCC 13032 and Mycobacterium tuberculosis H37Rv. We furthermore transferred the known networks of these model organisms to 18 other non-model but phylogenetically close species (target organisms) of the CMNR group. In comparison to other network transfers, for the first time we utilized two model organisms resulting into a more diverse and complete network of the target organisms. Conclusion: CMRegNet provides easy access to a total of 3,103 known regulations in C. glutamicum ATCC 13032 and M. tuberculosis H37Rv and to 38,940 evolutionary conserved interactions for 18 non-model species of the CMNR group. This makes CMRegNet to date the most comprehensive database of regulatory interactions of CMNR bacteria. The content of CMRegNet is publicly available online via a web interface found at http://lgcm.icb.ufmg.br/cmregnet. |
Palavras-chave: | Corynebacterium glutamicum Mycobacterium tuberculosis |
Título do Periódico: | BMC Genomics |
ISSN: | 1471-2164 |
País: | Reino Unido |
Instituição: | BioMed Central Ltd |
Tipo de Acesso: | Acesso Aberto Attribution-NonCommercial-NoDerivs 3.0 Brazil |
Fonte URI: | https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-1631-0#Ack1 |
Identificador DOI: | 10.1186/s12864-015-1631-0 |
Aparece nas coleções: | Artigos Científicos - ICB |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Article_CMRegNetInterspeciesReference.pdf | 3,56 MB | Adobe PDF | Visualizar/Abrir |
Este item está licenciado sob uma Licença Creative Commons