CMRegNet–An interspecies reference database for corynebacterial and mycobacterial regulatory networks

Carregando...
Imagem de Miniatura

Data

2015-06

Título da Revista

ISSN da Revista

Título de Volume

item.page.theme

Editora(s)

BioMed Central Ltd

Tipo de acesso

Acesso Aberto
Attribution-NonCommercial-NoDerivs 3.0 Brazilaccess-logo

Contido em

BMC Genomics

Citação

ABREU, Vinicius A. C. CMRegNet–An interspecies reference database for corynebacterial and mycobacterial regulatory networks. BMC Genomics, online, v. 16, n. 452, p. 1-10, 2015. DOI: https://doi.org/10.1186/s12864-015-1631-0. Disponível em: https://repositorio.ufpa.br/jspui/handle/2011/15723. Acesso em:.

DOI

10.1186/s12864-015-1631-0
Background: Organisms utilize a multitude of mechanisms for responding to changing environmental conditions, maintaining their functional homeostasis and to overcome stress situations. One of the most important mechanisms is transcriptional gene regulation. In-depth study of the transcriptional gene regulatory network can lead to various practical applications, creating a greater understanding of how organisms control their cellular behavior. Description: In this work, we present a new database, CMRegNet for the gene regulatory networks of Corynebacterium glutamicum ATCC 13032 and Mycobacterium tuberculosis H37Rv. We furthermore transferred the known networks of these model organisms to 18 other non-model but phylogenetically close species (target organisms) of the CMNR group. In comparison to other network transfers, for the first time we utilized two model organisms resulting into a more diverse and complete network of the target organisms. Conclusion: CMRegNet provides easy access to a total of 3,103 known regulations in C. glutamicum ATCC 13032 and M. tuberculosis H37Rv and to 38,940 evolutionary conserved interactions for 18 non-model species of the CMNR group. This makes CMRegNet to date the most comprehensive database of regulatory interactions of CMNR bacteria. The content of CMRegNet is publicly available online via a web interface found at http://lgcm.icb.ufmg.br/cmregnet.

Agência de Fomento

MMCI - Cluster of Excellence for Multimodal Computing and Interaction

browse.metadata.ispartofseries

item.page.isbn

Fonte

item.page.dc.location.country

Citação

ABREU, Vinicius A. C. CMRegNet–An interspecies reference database for corynebacterial and mycobacterial regulatory networks. BMC Genomics, online, v. 16, n. 452, p. 1-10, 2015. DOI: https://doi.org/10.1186/s12864-015-1631-0. Disponível em: https://repositorio.ufpa.br/jspui/handle/2011/15723. Acesso em:.