Please use this identifier to cite or link to this item:
metadata.dc.type: Artigo de Periódico
Issue Date: Dec-2009
metadata.dc.creator: GOUVEIA JUNIOR, Amauri
ANTUNES, Gabriela
OLIVEIRA, Caio Maximino de
CARVALHO, Silvio Morato de
Title: The effects of diazepam on the elevated T-maze are dependent on the estrous cycle of rats
Citation: GOUVEIA JR, Amauri et al. The effects of diazepam on the elevated T-maze are dependent on the estrous cycle of rats. Psychology & Neuroscience, Rio de Janeiro, v. 2, n. 2, p. 227-233, dez. 2009. Disponível em: <>. Acesso em: 29 fev. 2011.
Abstract: In order to determine the modulation of anxiolytic and panicolytic-like effects of diazepam by the hormonal cycle of female rats, male and female rats – the latter divided per estrous cycle phase (estrus, diestrus, metaestrus and proestrus) – were tested in the elevated T-maze, a behavioral model of panic and anxiety. Diazepam (0.5, 1.0 and 2.0 mg/kg) or saline solution was injected in individual animals that were submitted to one session in the elevated T-maze 25 min after drug/saline administration. The test consisted of three avoidance trials and one escape trial, separated by a 30 s interval, during which the animals were isolated in individual cages. The avoidance trials began with the animal being placed at the end of the maze's enclosed arm. The time necessary for the animal to leave the central square was considered as the response's latency. The trials that exceeded 300 s were considered as failures. Results demonstrate a decrease in the effects of diazepam in inhibitory avoidance (anxiety) trials in females in diestrus and proestrus, but no relation of gender or estrous cycle on diazepam effects on escape trials (fear). The results support the hypothesis that down-regulation of GABAA receptors by activation of nuclear estrogen receptors and induction of PKC-mediated GABAA receptor phosphorylation by activation of surface estrogen receptors in raphe neurons underlie the modulation of diazepam sensitivity by estrogen.
Keywords: Ansiedade
Comportamento animal
Farmacologia experimental
ISSN: 1983-3288
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICB

Files in This Item:
File Description SizeFormat 
Artigo_EffectsDiazepamElevated.pdf286,94 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons