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dc.creatorRODRÍGUEZ BURBANO, Rommel Mario-
dc.creatorLIMA, Eleonidas Moura-
dc.creatorKHAYAT, André Salim-
dc.creatorBARBIERI Neto, J.-
dc.creatorCABRAL, Isabel Rosa-
dc.creatorBASTOS JR., L.-
dc.creatorBAHIA, Marcelo de Oliveira-
dc.creatorCASARTELLI, Cacilda-
dc.identifier.citationBURBANO, R. R. et al. Cytogenetic description of breast fibroadenomas: alterations related solely to proliferation?. Brazilian Journal of Medical and Biological Research. Ribeirão Preto, v. 34, n. 8, p. 1003-1006, ago. 2001. Disponível em <>. Acesso em: 31 jan. 2013. <>.pt_BR
dc.description.abstractTwelve breast fibroadenomas were analyzed cytogenetically and only four were found to have clonal alterations. The presence of chromosomal alterations in fibroadenomas must be the consequence of the proliferating process and must not be related to the etiology of this type of lesion. In contrast, the few fibroadenomas that exhibit chromosomal alterations are likely to be those presenting a risk of neoplastic transformation. Clonal numerical alterations involved chromosomes 8, 18, 19, and 21. Of the chromosomal alterations found in the present study, only monosomy of chromosomes 19 and 21 has been reported in breast fibroadenomas. The loss of chromosome 21 was the most frequent alteration found in our sample. The study of benign proliferations and their comparison with chromosome alterations in their malignant counterparts ought to result in a better understanding of the genes acting on cell proliferation alone, and of the genes that cause these cells to exhibit varied behaviors such as recurrences, spontaneous regression and fast growth.pt_BR
dc.rightsAcesso Aberto-
dc.subjectNeoplasias da mamapt_BR
dc.subjectAlterações cromossômicaspt_BR
dc.titleCytogenetic description of breast fibroadenomas: alterations related solely to proliferation?pt_BR
dc.typeArtigo de Periódico-
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