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metadata.dc.type: Artigo de Periódico
Issue Date: Dec-2005
metadata.dc.creator: CARVALHAES, Fernanda Andreza de Pinho Lott
CARDOSO, Greice de Lemos
VALLINOTO, Antonio Carlos Rosário
MACHADO, Luiz Fernando Almeida
ISHAK, Marluísa de Oliveira Guimarães
ISHAK, Ricardo
GUERREIRO, João Farias
Title: Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia
Citation: CARVALHAES, Fernanda Andreza de Pinho Lott, et al. Frequencies of CCR5-D32, CCR2-64I and SDF1-3’A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia. Genetics and Molecular Biology. São Paulo, v. 28, n. 4, p. 665-669, out./dez. 2005. Disponível em: <>. Acesso em: 25 mar. 2013. <>.
Abstract: The distribution of genetic polymorphisms of chemokine receptors CCR5-D32, CCR2-64I and chemokine (SDF1-3 A) mutations were studied in 110 Human Immunodeficiency Virus type 1 (HIV-1) seropositive individuals (seropositive group) and 139 seronegative individuals (seronegative group) from the population of the northern Brazilian city of Belém which is the capital of the state of Pará in the Brazilian Amazon. The CCR5-D32 mutation was found in the two groups at similar frequencies, i.e. 2.2% for the seronegative group and 2.7% for the seropositive group. The frequencies of the SDF1-3 A mutation were 21.0% for the seronegative group and 15.4% for the seropositive group, and the CCR2-64I allele was found at frequencies of 12.5% for the seronegative group and 5.4% for the seropositive group. Genotype distributions were consistent with Hardy-Weinberg expectations in both groups, suggesting that none of the three mutations has a detectable selective effect. Difference in the allelic and genotypic frequencies was statistically significant for the CCR2 locus, the frequency in the seronegative group being twice that found in the seropositive group. This finding may indicate a protective effect of the CCR2-64I mutation in relation to HIV transmission. However, considering that the CCR2-64I mutation has been more strongly associated with a decreased risk for progression for AIDS than to the resistance to the HIV infection, this could reflect an aspect of population structure or a Type I error.
Keywords: Polimorfismo genético
Receptor CCR2
Receptor CCR5
Receptor SDF1
Síndrome de Imunodeficiência Adquirida
Frequência do gene
Belém - PA
Pará - Estado
Amazônia brasileira
ISSN: 1678-4685
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICB

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