Prevalência de auto-anticorpos contra antígenos celulares em pacientes com infecção pelos Vírus da dengue e Vírus linfotrópico de células T humanas, HTLV - 1 e 2

Abstract

The antibodies against cellular antigens requires ongoing review of information on the interpretation of results, whereas the positivity is observed in the normal population and transiently triggered by infectious processes. The objective of this study was to determine, through the technique for auto-anti-nuclear antibody (ANA) on HEp-2, the prevalence of autoantibodies to cellular antigens in three groups: Group 1 - infected patients Dengue virus (RV) (n = 30), Group 2 - patients infected by HTLV 1 and 2 (n = 30) Group 3 - blood donors (n = 100) uninfected and without apparent clinical manifestations. The prevalence of ANA in Group 1 (40%) and 2 (40%) was highly significant compared to Group 3 (2%) (p <0.0001), predominantly cytoplasmic pattern in relation to nuclear pattern. Individuals in Group 1 were infected by three species of the RV, with prevalence (p = 0.002) for the DEN 3 (66.7%), though the frequency distribution of NAA in accordance with the species showed a significant difference (p = 0.0260) between VD1 infections (p = 0.0644) and VD2 (p = 0.0249), compared to VD3, but no difference between the patterns (p = 0.2479). In Group 2, the prevalence and pattern of ANA showed no correlation with the type of HTLV, although dominated individuals infected with HTLV 1 (p = 0.0035) (76.7%), most had no clinical symptoms (p = 0 , 0136), 36.7% showed disease compatible with HAM / TSP, and the presence of NAA showed no significant difference between symptomatic and asymptomatic patients (p> 0.05). There was no correlation of seropositivity with sex between the groups. It was concluded that the stage of infection is an important trigger of autoimmune responses detected by laboratory testing, with no significant influence on the clinical manifestations of diseases. Prospective studies, with controls these cases, may bring answers regarding the importance and significance of the results.