Use este identificador para citar ou linkar para este item:
https://repositorio.ufpa.br/jspui/handle/2011/6119
Tipo: | Artigo de Periódico |
Data do documento: | Dez-2012 |
Autor(es): | DINIZ, Daniel Guerreiro FÔRO, César Augusto Raiol TURIEL, Maíra Catherine Pereira SÓSTHENES, Márcia Consentino Kronka DEMACHKI, Samia GOMES, Giovanni Freitas REGO, Carla M Damasceno MAGALHÃES, Marina Cutrim PINHO, Brunno Gomes RAMOS, Juliana Pastana CASSEB, Samir Mansour Moraes BRITO, Maysa de Vasconcelos SILVA, Eliana Vieira Pinto da NUNES, Márcio Roberto Teixeira DINIZ JUNIOR, José Antônio Picanço CUNNINGHAM, Colm PERRY, Victor Hugh VASCONCELOS, Pedro Fernando da Costa DINIZ, Cristovam Wanderley Picanço |
Título: | Environmental influences on antibody-enhanced dengue disease outcomes |
Citar como: | DINIZ, Daniel Guerreiro et al. Environmental influences on antibody-enhanced dengue disease outcomes. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 8, p. 1021-1029, dez. 2012. Disponível em: <http://www.scielo.br/pdf/mioc/v107n8/10.pdf>. Acesso em: 25 nov. 2014. <http://dx.doi.org/10.1590/S0074-02762012000800010>. |
Abstract: | Because an enriched environment (EE) enhances T-cell activity and T-lymphocytes contribute to immunopathogenesis during heterologous dengue virus (DENV) infections, we hypothesised that an EE increases dengue severity. To compare single serotype (SS) and antibody-enhanced disease (AED) infections regimens, serial intraperitoneal were performed with DENV3 (genotype III) infected brain homogenate or anti-DENV2 hyperimmune serum followed 24 h later by DENV3 (genotype III) infected brain homogenate. Compared AED for which significant differences were detected between the EE and impoverished environmental (IE) groups (Kaplan-Meyer log-rank test, p = 0.0025), no significant differences were detected between the SS experimental groups (Kaplan-Meyer log-rank test, p = 0.089). Survival curves from EE and IE animals infected with the AED regimen were extended after corticoid injection and this effect was greater in the EE than in the IE group (Kaplan-Meyer log-rank test, p = 0.0162). Under the AED regimen the EE group showed more intense clinical signs than the IE group. Dyspnoea, tremor, hunched posture, ruffled fur, immobility, pre-terminal paralysis, shock and death were associated with dominant T-lymphocytic hyperplasia and presence of viral antigens in the liver and lungs. We propose that the increased expansion of these memory T-cells and serotype cross-reactive antibodies facilitates the infection of these cells by DENV and that these events correlate with disease severity in an EE. |
Palavras-chave: | Doenças infecciosas Dengue Influência ambiental Linfócitos T |
ISSN: | 0074-0276 |
Tipo de Acesso: | Acesso Aberto |
Aparece nas coleções: | Artigos Científicos - HUJBB |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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Artigo_ EnvironmentalInfluencesAntibodyenhanced.pdf | 2,01 MB | Adobe PDF | Visualizar/Abrir |
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