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metadata.dc.type: Artigo de Periódico
Issue Date: Jul-2009
metadata.dc.creator: SOUSA, Pergentino José da Cunha
LINARD, Cybelle Facanha Barreto Medeiros
BATISTA, Danilo de Azevedo
OLIVEIRA, Ariclécio Cunha de
SOUZA, Andrelina Noronha Coelho de
CARDOSO, José Henrique Leal
Title: Antinociceptive effects of the essential oil of Mentha x villosa leaf and its major constituent piperitenone oxide in mice
Citation: SOUSA, P.J.C. et al. Antinociceptive effects of the essential oil of Mentha x villosa leaf and its major constituent piperitenone oxide in mice. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 42, n. 7, p. 655-659, jul. 2009. Disponível em: <>. Acesso em: 23 abr. 2015. <>.
Abstract: Mentha x villosa Huds (Labiatae) is an aromatic herb widely used in folk medicine. Since the essential oil of the herb has many pharmacological activities, including antispasmodic effects, we determined whether the oil and its major constituent, piperitenone oxide (PO), have antinociceptive activity. The essential oil of M. x villosa (EOMV) and PO administered orally at 200 mg/kg (vehicle: 0.1% Tween 80 in water) significantly reduced the writhings induced by acetic acid from control values of 59.5 ± 3.1 s (N = 10) to 31.9 ± 2.8 s (N = 10) and 23.8 ± 3.4 s (N = 10), respectively. When administered at 100 and 200 mg/kg, EOMV reduced the paw licking time for the second phase of the formalin test from the control value of 20.6 ± 2.1 s (N = 13) to 5.3 ± 2.2 s (N = 12) and 2.7 ± 1.2 s (N = 18), respectively. At 100 and 200 mg/kg, PO reduced this second phase to 8.3 ± 2.7 s (N = 12) and 3.0 ± 1.2 s (N = 10), respectively. This effect of EOMV and PO was not reversed by naloxone. EOMV and PO had no significant effect on the first phase of the formalin test. As evaluated by the hot-plate and tail immersion test, EOMV and PO, at doses up to 200 mg/kg, showed no analgesic activity. These results show that EOMV and PO have antinociceptive activity and suggest that this effect is probably an indirect anti-inflammatory effect, which does not involve the central nervous system.
Keywords: Óleo essencial
Mentha x villosa
Óxido piperitenone
ISSN: 1414-431X
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - FARM/ICS

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