Use este identificador para citar ou linkar para este item:
https://repositorio.ufpa.br/jspui/handle/2011/6876
Tipo: | Artigo de Periódico |
Data do documento: | 2009 |
Autor(es): | LIMA, Magaly do Bom Parto Lopes Vieira OLIVEIRA FILHO, Aldemir Branco de CAMPOS, Júlia Furtado MELO, Fárida Coeli de Barros Correia NEVES, Washington Batista das MELO, Raul Antônio Morais LEMOS, José Alexandre Rodrigues de |
Título: | Increased risk of venous thrombosis by AB alleles of the ABO blood group and Factor V Leiden in a Brazilian population |
Citar como: | LIMA, Magaly do Bom Parto Lopes Vieira et al. Increased risk of venous thrombosis by AB alleles of the ABO blood group and Factor V Leiden in a Brazilian population. Genetics and Molecular Biology, São Paulo, v. 32, n. 2, p. 264-267, 2009. Disponível em: <http://www.scielo.br/pdf/gmb/v32n2/a10v32n2.pdf>. Acesso em: 8 set. 2015. <http://dx.doi.org/10.1590/S1415-47572009000200010>. |
Abstract: | Most cases of a predisposition to venous thrombosis are caused by resistance to activated protein C, associated in 95% of cases with the Factor V Leiden allele (FVL or R506Q). Several recent studies report a further increased risk of thrombosis by an association between the AB alleles of the ABO blood group and Factor V Leiden. The present study investigated this association with deep vein thrombosis (DVT) in individuals treated at the Hemocentro de Pernambuco in northeastern Brazil. A case-control comparison showed a significant risk of thrombosis in the presence of Factor V Leiden (OR = 10.1), which was approximately doubled when the AB alleles of the ABO blood group were present as well (OR = 22.3). These results confirm that the increased risk of deep vein thrombosis in the combined presence of AB alleles and Factor V Leiden is also applicable to the Brazilian population suggesting that ABO blood group typing should be routinely added to FVL in studies involving thrombosis. |
Palavras-chave: | Trombose venosa Fator V Leiden Sistema do grupo sanguíneo ABO Pernambuco - Estado |
ISSN: | 1678-4685 |
Tipo de Acesso: | Acesso Aberto |
Aparece nas coleções: | Artigos Científicos - ICB |
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