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metadata.dc.type: Artigo de Periódico
Issue Date: Dec-2016
metadata.dc.creator: OHASHI, Camila Melo
CALDEIRA, Fabio Alves Morikawa
FEITOSA JUNIOR, Denilson José Silva
VALENTE, André Lopes
DUTRA, Paulo Roberto Witter
MIRANDA, Moysés dos Santos
SANTOS, Simone do Socorro Damasceno
BRITO, Marcus Vinicius Henriques
OHASHI, Otávio Mitio
YASOJIMA, Edson Yuzur
Title: Stem cells from adipose tissue improve the time of wound healing in rats
Citation: OHASHI, Camila Melo et al. Stem cells from adipose tissue improve the time of wound healing in rats. Acta Cirúrgica Brasileira, São Paulo, v. 31, n. 12, p. 821-825, Dec. 2016. DOI: Disponível em: Acesso em:.
Abstract: PURPOSE: To evaluate the Adipose Stem Cells (ACS) therapy efficacy on the time and quality of wound healing process in rats. METHODS: Nine male Wistar rats were randomly distributed into three groups I) 7 days of healing; II) 14 days of healing; III) 21 days of healing. Four incisions were made on the dorsal surface of each rat and then treated with intralesional ACS, meloxicam, and no treatment and ACS+meloxicam. Macroscopic evaluation was measured by percentage of healing and histopathological by hematoxylineosin was performed. RESULTS: All groups have the wound reduced during the three weeks (p<0.001) and after 14 days of healing had greater reduction than others. Wounds treated with ASC had accelerated healing in relation to no treatment and only meloxicam (p<0.001), excepting the ASC+Meloxicam that was similar (p=0.13). There was no difference in histopathological analysis between lesions. CONCLUSION: Adipose stem cell have benefits in reducing time of healing of experimental model of wound in rats, observed 7 days of after application.
Keywords: Células-tronco
Tecido adiposo
Adipose tissue
Wound healing
Stem cells
Series/Report no.: Acta Cirúrgica Brasileira
ISSN: 1678-2674 Brasil
Publisher: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
metadata.dc.publisher.initials: SOBRADPEC
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICS

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