Please use this identifier to cite or link to this item: https://repositorio.ufpa.br/jspui/handle/2011/9588
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dc.creatorSOUZA, Ana Maria Almeida-
dc.creatorMUNIZ, Thiago Pimentel-
dc.creatorBRITO, Rafael Maciel-
dc.date.accessioned2018-03-19T13:11:40Z-
dc.date.available2018-03-19T13:11:40Z-
dc.date.issued2014-10-
dc.identifier.citationSOUZA, Ana Maria Almeida; MUNIZ, Thiago Pimentel; BRITO, Rafael Maciel. Study of enzyme replacement therapy for Gaucher Disease: comparative analysis of clinical and laboratory parameters at diagnosis and after two, five and ten years of treatment. Revista Brasileira de Hematologia e Hemoterapia, São José do Rio Preto, v. 36, n. 5, p. 345-350, out. 2014. Disponível em: <http://repositorio.ufpa.br/jspui/handle/2011/9588>. Acesso em:pt_BR
dc.identifier.issn1516-8484pt_BR
dc.identifier.urihttp://repositorio.ufpa.br/jspui/handle/2011/9588-
dc.description.abstractObjective: to evaluate the impact of enzyme replacement therapy for Gaucher Disease on clinical and laboratory parameters after two, five and ten years of treatment. Methods: data were collected from patient records and analyzed using BioEstat software (version 5.0). Student's t-test, Analysis of Variance (ANOVA), Wilcoxon test and Kruskal–Wallis test were used for statistical analysis. Hepatomegaly and splenomegaly were analyzed using the Kappa test. Results: there was a significant increase in hemoglobin levels (p-value <0.01) and platelet counts (p-value = 0.01) within two years of therapy. At the same time, the frequencies of splenomegaly (p-value <0.01) and hepatomegaly (p-value <0.05) reduced. These results were similar at five and ten years of enzyme replacement therapy. Conclusions: there are substantial and quick (within two years) laboratory and clinical responses to enzyme replacement therapy. These improvements continue as long as enzyme replacement therapy is administered every two weeks, as recommended by the literature.pt_BR
dc.description.provenanceSubmitted by Rose Suellen (rosesuellen@ufpa.br) on 2018-03-19T13:08:13Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Artigo_StudyEnzymeReplacement.pdf: 555371 bytes, checksum: 28cadc0b1d8fd434762fffe700a61a93 (MD5)en
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dc.description.provenanceMade available in DSpace on 2018-03-19T13:11:40Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Artigo_StudyEnzymeReplacement.pdf: 555371 bytes, checksum: 28cadc0b1d8fd434762fffe700a61a93 (MD5) Previous issue date: 2014-10en
dc.languageengpt_BR
dc.publisherUniversidade Federal do Parápt_BR
dc.relation.ispartofRevista Brasileira de Hematologia e Hemoterapiapt_BR
dc.rightsAcesso Abertopt_BR
dc.source.urihttp://www.scielo.br/pdf/rbhh/v36n5/1516-8484-rbhh-36-05-0345.pdfpt_BR
dc.subjectDoença de Gaucherpt_BR
dc.subjectEsplenomegaliapt_BR
dc.subjectAnemiapt_BR
dc.subjectTerapia de substituição enzimáticapt_BR
dc.titleStudy of enzyme replacement therapy for Gaucher Disease: comparative analysis of clinical and laboratory parameters at diagnosis and after two, five and ten years of treatmentpt_BR
dc.typeArtigo de Periódicopt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.initialsUFPApt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDEpt_BR
dc.creator.Latteshttp://lattes.cnpq.br/7354732879818383pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/6173084583474707pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/0252965338736094pt_BR
dc.citation.volume36pt_BR
dc.citation.issue5pt_BR
dc.citation.spage345pt_BR
dcterms.citation.epage350pt_BR
dc.identifier.doihttp://dx.doi.org/10.1016/j.bjhh.2014.05.005pt_BR
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