2013-12-062013-12-062013-05-27ALBUQUERQUE, Thayana Lucy Freitas. Análise nutricional e atividade antinociceptiva do óleo Plukenetia polyadenia. 2013. 81 f. Dissertação (Mestrado) - Universidade Federal do Pará, Instituto de Ciências Biológicas, Belém, 2013. Programa de Pós-Graduação em Neurociências e Biologia Celular.https://repositorio.ufpa.br/handle/2011/4507This study investigated the nutritional effects resulting from chronic oral administration of oil Plukenetia polyadenia in rats on weight, feed intake, blood lipid composition, and histology of the organs, and to investigate the toxicity and antinociceptive activity after administration of different dosages orally in mice. The nutritional analysis of food intake and weight showed that chronic administration of this oil did not interfere nutritionally in the homeostasis of these variables, regardless of the dosages used (100 and 200mg.kg/weight). The lipid fractions of blood as total cholesterol, LDL, HDL and triglycerides also are unchanged in the supplemented animals. Not found edema, cell death or cell inflammatory response in the liver, heart, lung, stomach, intestines, pancreas and chronic renal after supplementation in both dosages. In the writhing test induced by acetic acid, the oil administered orally (25, 50 and 100mg.kg/ weight) significantly reduced the number of writhes compared to the control. In the hot plate test, the treatment with oil at a dosage of 200mg.kg/weight induced no change in latency to thermal stimulus compared to the control. In the formalin test, oral treatment at doses of 50 and 100mg.kg/ weight showed a significant antinociceptive effect, reducing the time to lick only in the second phase (inflammatory). The oil in 200mg.kg/ weight dosage did not affect the behavioral activity of rats submitted to the open field test and showed no toxic effects. Our results demonstrated that Plukenetia polyadenia present antinociceptive activity without toxicicity.porAcesso AbertoPlukenetia polyadeniaAtividade antinociceptivaAnálise nutricionalDissertaçãoCNPQ::CIENCIAS DA SAUDE::NUTRICAO