2015-11-302015-11-302012-06GOMES, Fabíola Silveira; SILVA, Silvia Helena Marques da. Effect of serum sample inactivation on the performance of latex agglutination test for paracoccidioidomycosis serodiagnosis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 4, p. 510-512, jun. 2012. Disponível em: <http://www.scielo.br/pdf/mioc/v107n4/11.pdf>. Acesso em: 16 nov. 2015. <http://dx.doi.org/10.1590/S0074-02762012000400011>.0074-0276https://repositorio.ufpa.br/handle/2011/7035Paracoccidioidomycosis is diagnosed from the direct observation of the causative agent, but serology can facilitate and decrease the time required for diagnosis. The objective of this study was to determine the influence of serum sample inactivation on the performance of the latex agglutination test (LAT) for detecting antibodies against Paracoccidioides brasiliensis. The sensitivity of LAT from inactivated or non-inactivated samples was 73% and 83%, respectively and the LAT selectivity was 79% and 90%, respectively. The LAT evaluated here was no more specific than the double-immunodiffusion assay. We suggest the investigation of other methods for improving the LAT, such as the use of deglycosylated antigen.engAcesso AbertoParacoccidioidomicoseDiagnóstico sorológicoTeste de aglutinação em latexArtigo de Periódico