2022-06-082022-06-082017-11-30DIAS, Amarílis Aragão. Síntese, intercalação, caracterização estrutural e análise biológica de nanopartícula carreadora de ácido kójico. Orientador: Cláudio Nahum Alves. 2017. 49 f. Dissertação (Mestrado em Química Medicinal e Modelagem Molecular) - Programa de Pós-graduação em Química Medicinal e Modelagem Molecular, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2017. Disponível em: http://repositorio.ufpa.br:8080/jspui/handle/2011/14440. Acesso em:.https://repositorio.ufpa.br/handle/2011/14440Intercalation of species with pharmacological activity in layered double hydroxides (LDHs) is a growing field in academic and industrial research, these compounds are capable of promoting the controlled release of drugs. In this work we merge the kojic acid in LDH nanoparticles of Mg2+/Al3+ by co-precipitation method. This substance has many applications in various fields of research, however it is easily susceptibile to photo-oxidation which causes organoleptic and chemical modifications of its structure. Recently kojic acid was introduced as a potent inhibitor of Leishmania cultures, we believe that the particular properties of HDL, such as photoprotection, and stabilization of the interleaved facilitate the production of a material resistant to possible applications for health. All samples were prepared by the co-precipitation method, were further characterized by X-ray diffraction, Raman, IR, UV-vis spectroscopy, thermogravimetry, and biological evaluations of Leishmania cultures. Our results demonstrate that HDL has 53.018% AK intercalated kojic acid and is able to withstand high temperatures, in addition to having an anti-leishmania potential.Acesso AbertoAttribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/Hidróxidos duplos lamelaresNanopartículasÁcido kójicoAnti-leishmaniaLayered double hydroxidesNanoparticlesKojic acidAnti-leishmaniaDissertaçãoCNPQ::CIENCIAS DA SAUDE::FARMACIA::QUIMICA MODULARMODELAGEM MOLECULAR E SIMULAÇÃO COMPUTACIONAL DE SISTEMAS BIOMOLECULARESQUÍMICA MEDICINAL