2022-06-072022-06-072020-12-21ANJOS, Maricelia Lopes dos. Síntese, caracterização e avaliação da atividade antimicrobiana e antiproliferativa de chalconas e derivados- in vitro. Orientador: Heriberto Rodrigues Bitencourt. 2020. 79 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Federal do Pará, Instituto de Ciências da Saúde, Belém, 2020. Disponível em: http://repositorio.ufpa.br:8080/jspui/handle/2011/14432. Acesso em:.https://repositorio.ufpa.br/handle/2011/14432In the present work we perform the synthesis, characterization and evaluation of antimicrobial and antiproliferative activities of chalcones and derivatives - in vitro. The interest in obtaining chalcones is due to the numerous pharmacological activities described in the literature for these classes of compounds that are intermediates for flavonoids. Thus, the synthesis and characterization of various chalcones and derivatives become important for the development of compounds with antimicrobial and antiproliferative activity. Ten substances were synthesized, containing seven chalcones and three naphthoflavanones, obtained by the Claisen Schmidt aldolic condensation reaction between acetophenones and aldehydes, at room temperature or with heating. Yields varied between 65.35% and 97.45%. Being characterized and confirmed by spectroscopic techniques. The antimicrobial activity in vitro was analyzed in the strains: Staphylococcus aureus; Enterococcus faecalis; Escherichia coli and Pseudomonas aeruginosa, following the microdilution protocol, however their inhibition result was not satisfactory. All substances were submitted to the cell viability test (MTT), to evaluate the antiproliferative activity in vitro, in gastric tumor line (AGP01), with comparison of dose response to the normal lung cell line (MRC-5). The substances AMB, 34M, MEB, PEB and EBA, showed significant cytotoxic activity. Which may represent new pharmacological possibilities, even because they have not been tested in this cell line.Acesso AbertoAntimicrobianaAntiproliferativaAGP01ChalconasAntimicrobialAntiproliferativeChalconesDissertaçãoCNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIAAVALIAÇÃO BIOLÓGICA DE PRINCÍPIOS ATIVOS, NATURAIS E SINTÉTICOSFÁRMACOS E MEDICAMENTOS