2017-03-072017-03-072016-12OHASHI, Camila Melo et al. Stem cells from adipose tissue improve the time of wound healing in rats. Acta Cirúrgica Brasileira, São Paulo, v. 31, n. 12, p. 821-825, Dec. 2016. DOI: http://dx.doi.org/10.1590/s0102-865020160120000007. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/7800. Acesso em:.1678-2674https://repositorio.ufpa.br/handle/2011/7800PURPOSE: To evaluate the Adipose Stem Cells (ACS) therapy efficacy on the time and quality of wound healing process in rats. METHODS: Nine male Wistar rats were randomly distributed into three groups I) 7 days of healing; II) 14 days of healing; III) 21 days of healing. Four incisions were made on the dorsal surface of each rat and then treated with intralesional ACS, meloxicam, and no treatment and ACS+meloxicam. Macroscopic evaluation was measured by percentage of healing and histopathological by hematoxylineosin was performed. RESULTS: All groups have the wound reduced during the three weeks (p<0.001) and after 14 days of healing had greater reduction than others. Wounds treated with ASC had accelerated healing in relation to no treatment and only meloxicam (p<0.001), excepting the ASC+Meloxicam that was similar (p=0.13). There was no difference in histopathological analysis between lesions. CONCLUSION: Adipose stem cell have benefits in reducing time of healing of experimental model of wound in rats, observed 7 days of after application.Acesso AbertoCélulas-troncoTecido adiposoCicatrizaçãoHistologiaAdipose tissueWound healingStem cellsRatsStem cells from adipose tissue improve the time of wound healing in ratsArtigo de Periódicohttp://dx.doi.org/10.1590/s0102-865020160120000007