2017-02-012017-02-012015-03-20PEREIRA, Rayanne Rocha. Obtenção e caracterização de sistemas líquido cristalinos contendo óleo de açaí (euterpe Oleraceae Mart.). 2015. 102 f. Dissertação (Mestrado) - Universidade Federal do Pará, Instituto de Ciências da Saúde, Belém, 2015. Programa de Pós-Graduação em Ciências Farmacêuticas.https://repositorio.ufpa.br/handle/2011/7521The Euterpe oleracea Mart. is an Amazonian palm tree, popularly known as acai. From the pulp of the acai fruit can extract the fixed oil, consisting mainly of fatty mono and polyunsaturated acids. This oil is a promising raw material for the pharmaceutical industry, which can be exploited by their biological activities and as a raw material in the development of sustained drug delivery systems. Liquid crystals are examples of sustained drug delivery systems. The objective of this study was to develop liquid crystalline systems containing acai oil as the oil phase and the Procetyl AWS as surfactant. Initially acai oil was analyzed for its physical and chemical characteristics. Gas chromatography revealed oleic acid (47.58%), palmitic acid (24.06%) and linoleic acid (13.58%) as major constituents. The physicochemical characterization showed values of acidity, iodine, saponification, refraction and density within the limits and recommended standards. Spectroscopy in the infrared region showed characteristic bands of acai oil. Thermogravimetry açai oil showed a unique event that possibly due to the degradation of fatty acids, this event is located in the temperature range of 241.71 to 481,14ºC. The acai oil induction time was 11,79h. The pre-formulation studies with acai oil and the surfactants showed no evidence of chemical interaction or resulting degradation of binary mixture between the oil and the Procetyl AWS. Formulations were prepared 36 with the aid of ternary diagram between these formulations were identified hexagonal and cubic mesophases. The rheological analysis showed pseudoplastic behavior (n <1) with plastic characteristics that refer to the Bingham fluids. The stability study conducted over 30 days did not reveal any signs of instability of the evaluated systems. The realization of this study demonstrated that the acai oil is a promising raw material in the development of sustained drug delivery system.Acesso AbertoÓleos vegetaisÓleo de açaíAçaíPalmeira (Vegetal)Euterpe oleraceaFármacosDissertaçãoCNPQ::CIENCIAS DA SAUDE::FARMACIA::ANALISE E CONTROLE E MEDICAMENTOS