2018-12-122018-12-122013-06-12SANTOS, Bruno Rodrigues. Validação farmacológica da esquiva Inibitória do Danio Rerio. Orientador: Amauri Gouveia Junior. 2013. 59 f. Tese (Doutorado em Teoria e Pesquisa do Comportamento) - Núcleo de Teoria e Pesquisa do Comportamento, Universidade Federal do Pará, Belém, 2013. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/10470. Acesso em:.https://repositorio.ufpa.br/handle/2011/10470The Danio rerio is a fish species widely used in emerging models of anxiety due to well described behavior, anatomy, neuroanatomy and biochemistry. The inhibitory avoidance test is an anxiety-related parameters in the model development that described a suppressed behavior emitted to avoid an aversive stimulus. This experiment aimed to describe the inhibitory avoidance averssiveness of white side and the pharmacological validation of this test by using the following drugs: antidepressants - fluoxetine (5, 10 and 20 mg/kg) and imipramine (4, 8 and 16 mg/kg), anxiolytics - diazepam (0.06, 1.25 and 2 , 5 mg/kg) and clonazepam (0.02, 0.05 and 1.10 mg/kg), and stimulants - diethylpropion (2.5, 5 and 10 mg/kg) and caffeine (10, 20 and 40 mg/kg). The data confirm the aversiveness of the white side in inhibitory avoidance test. Flouxetine, imipramine, caffeine and dietilpropione have anxiogenic-like effect and imapaired inhibitory avoidance, excluding imipramine 8 mg/kg who facilitates its acquisition. Diazepam also facilitates inhibitory avoidance acquisition and clonazepam show anxiolytic-like effect on this test. These data show the effectiveness of inhibitory avoidance test as a model to study axiety.Acesso AbertoDanio rerioAnsiedadePreferência Claro/EscuroEsquiva InibitóriaAnxietyLight/Dark PreferenceInhibitory avoidanceTeseCNPQ::CIENCIAS HUMANASCNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA::FARMACOLOGIA GERALPROCESSOS EVOLUTIVOS E COMPORTAMENTO DE ORGANISMOS INFRA-HUMANOSECOETOLOGIA