2019-01-312019-01-312017-07-04GOMES, Rafaelli de Souza. Atividade imunomoduladora e antioxidante da saliva do Aedes aegypti em modelo de sepse. Orientadora: Marta Chagas Monteiro. 2017. 86 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2017. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/10552. Acesso em:.https://repositorio.ufpa.br/handle/2011/10552Sepsis is an organ dysfunction caused by a dysregulated immune response to an infection, the initial therapeutic approach to sepsis are broad spectrum antimicrobials, which is not sufficient for control of infection, requiring association with other therapies focused in the interruption of the inflammatory response chain, provided by the pathogens. In this way, the Aedes Aegypti’s saliva presents immunomodulary features, with a potential pro inflammatory cytokine inhibition, as well as the presence of nitric oxide peptides activators. Therefore, it would be a great interest to search the saliva’s immunomodulator effect in animal model sepses. In this regards, mices were pre treated with Aedes aegypti saliva, and sepsis was induced by the cecal ligation and puncture. After 12 and 24 hours, the samples were collected, and evaluated the survival rate, bacteria level, leukocyte migration, and oxidative parameters (NO, EROs, MDA e TEAC). The saliva improved the animal prognostic, increasing the survival rate and weight. Furthermore, decreased the bacterial levels and increased the influx of monocytes. The saliva, in addition, presented antioxidant effects by reducing production of the reatives species, and increasing the antioxidant capacity, other than decrease the lipid peroxidation. Thus, the saliva was capable to inhibit damages caused by sepsis in animals in vivo, improving its prognostic.Acesso AbertoSepseSalivaAedes aegyptiAntioxidantesAtividade imunomoduladora e antioxidante da saliva do Aedes aegypti em modelo de sepseEvaluation of immunomodulary activity of Aedes aegypti’s saliva in a sepsis modelDissertaçãoCNPQ::CIENCIAS DA SAUDE::FARMACIA::FARMACOGNOSIAAVALIAÇÃO BIOLÓGICA DE PRINCÍPIOS ATIVOS, NATURAIS E SINTÉTICOSFÁRMACOS E MEDICAMENTOS