2017-10-242017-10-242016BORGES, Bruna Emanuelle Sanches. Estresse oxidativo associado à infecção pelo hpv e às lesões precursoras do câncer de colo uterino em mulheres ribeirinha. 2016. 88 f. Dissertação (Mestrado) – Universidade Federal do Pará, Núcleo de Medicina Tropical, Belém, 2016. Programa de Pós-Graduação em Doenças Tropicais.https://repositorio.ufpa.br/handle/2011/9187This study aimed to evaluate the responses of oxidative stress associated with HPV infection and precursor lesions of cervical cancer in women riverside of the Amazon. Involved 126 riverside women two Itaituba city communities, 68 riverine two communities of Limoeiro do Ajurú and 43 women of a community of Braganca city district, all in the state of Para, aged 14 to 60 years, attended the cervical Cancer Prevention Program Uterine (PCCU) in the years 2013 and 2014. Was realized the Pap test and PCR (polymerase chain reaction) to HPV detection. Collection of blood samples were also obtained for evaluation of lipid peroxidation (MDA) and determination of total glutathione (GSHt) and oxidized (GSSG). Sociodemographic information was obtained during an interview prior to the collection. MDA levels were higher in those with HPV infection in all communities studied and those with low-grade precursor lesions in Itaituba. In Limoeiro do Ajurú and Bragança women the concentrations of total GSH and GSSG were presented suggesting high expression of an oxidative response in women with pre-malignant lesions of low grade uterine or cervical HPV. While women with HPV Itaituba LIEBG or the full GSH levels were higher than GSSG levels, suggesting the antioxidant GSH response. Which is the first work that investigates responses of oxidative stress associated with pre-malignant lesions of cervical cancer and HPV infection in riverside communities in the Amazon, the results showed a significant association between oxidative responses and HPV infection, become relevant studies which investigate the main factors influencing the responses of oxidative stress in this population.Acesso AbertoDoença sexualmente transmissível (DST)Câncer do Colo do ÚteroPapilomavírusEstresse oxidativoSaúde da mulherPará - EstadoAmazônia brasileiraDissertaçãoCNPQ::CIENCIAS DA SAUDE::SAUDE COLETIVA::SAUDE PUBLICACNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA::CANCEROLOGIACNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA::GINECOLOGIA E OBSTETRICIA