2019-01-302019-01-302017-06-28SANTOS, Everton Renan Quaresma dos. Óleos essenciais ricos em linalol (Aniba Rosaeodora, A. Parviflora e Aeollanthus Suaveolens) na Amazônia e seus efeitos neurocomportamentais em roedores. Orientador: José Guilherme Soares Maia. 2017. 76 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2017. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/10542. Acesso em:.https://repositorio.ufpa.br/handle/2011/10542Essential oils from the Amazon, rich in linalool (Aniba rosaeodora Ducke, rosewood; A. parviflora (Meisn.) Mez, macacaporanga; and Aeollanthus suaveolens Mart. Ex Spreng, catinga-de-mulata), are capable of interacting with the central nervous system (CNS). The objective of this work was to evaluate the neurobehavioral effects of these oils in rodents. The oils were extracted and analyzed for their chemical composition, where the main constituent was linalool (rosewood, 88.6%; macacaporanga, 45%; and catinga-de-mulata, 49.3%). Linalool is an oxygenated monoterpene commonly found in various essential oils used in perfumes and fragrances. The Male Wistar rats received by intraperitoneal the oils of rosewood (doses of 3.5 and 35 mg/kg), macacaporanga (doses of 8.5 and 85 mg/kg), catinga-de-mulata (doses of 7, 5 and 75 mg/kg) and the linalool standard (30 mg/kg). The oils and linalool were administered 30 minutes prior to testing. Afterwards, the animals were evaluated in the open field tests, high cross labyrinth, splash, forced swimming and inhibitory avoidance. The results showed that rosewood, macacaporanga, and catinga-de-mulata oils (at the highest dose administered), as well as the standard linalool, have antidepressant-type activity. In the splash test, there was a significant reduction in latency to initiate self-cleaning behavior and the increase self-cleaning time, except for macacaporanga oil, in this last parameter. In the forced swim test, there was a significant reduction in the immobility time of the animals. The oils tested showed antidepressant activity due to the presence of linalool, without interfering with spontaneous locomotion and memory formation.Acesso AbertoSaúde mentalManifestações neurocomportamentaisAntidepressivosEssências e óleos essenciaisRatos WistarÓleos essenciaisLinalolAniba RosaeodoraAniba ParvifloraAeollanthus SuaveolensPau rosaMacacaporangaCatinga-de-mulataDissertaçãoCNPQ::CIENCIAS DA SAUDE::FARMACIA::ANALISE E CONTROLE E MEDICAMENTOSAVALIAÇÃO BIOLÓGICA DE PRINCÍPIOS ATIVOS, NATURAIS E SINTÉTICOSFÁRMACOS E MEDICAMENTOS