2018-04-132018-04-131991-07-03SANTOS, Lourivaldo da Silva. Síntese e atividade biológica de neolignanas 8.0.4' derivados e compostos correlatos. 1991. 385 f. Tese (Doutorado) - Universidade Estadual de Campinas, Instituto de Química, Campinas, 1991. Programa de Pós-Graduação em Química. Disponível em: <http://repositorio.ufpa.br/jspui/handle/2011/9760>. Acesso em:.https://repositorio.ufpa.br/handle/2011/9760We have synthesized ca. 80 different aromatic compounds (8.0.4' -neolignans several derivatives and correlated compounds containing or 5 at C-8). These substances were submitted to bioassays namely PAF antagonists anti-leishmaniasis antibacteria, anti-schistossomose and anti-fungi. From the Virola surinmensin leaves we have isolated a 8.0.4' -neolignan, (+) -surinamensin whose absolute configuration was determinated as (+)-7S, 8S-surinamensin. Using crown ethers associated with metalic hydrides we have performed studies on the reduction stereoselectivity aiming a high diastereoselectivity of the β-ketoether reductions. We have also developed the first synthetic pathway Ieading to the enantiomerically pure 8.0.4' -neolignans using (+) - and (-) -Dimethyl tartrate as the chiral auxiliary groups which was sucessfulIy applied to the synthesis of (+) -virolin. Also we obtained chiral β -ketosulfides using the same route described earlier in an enantiosselectice pathway. Finnally, using safrol and eugenol abundant Brazilian raw material, we developed an alternative synthetic rout to the neolignans having bromohydrin as intermediate.Acesso AbertoCompostos aromáticosQuímica orgânicaTeseCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA ORGANICA::QUIMICA DOS PRODUTOS NATURAIS