2026-01-212026-01-212025-07-04ARAÚJO, Andréia de Fátima Souza. Metodologia de preparação de enxaguante bucal à base de acmella oleracea com o uso de tecnologia supercrítica. Orientador: Raul Nunes de Carvalho Junior. 2025. 59f. Tese (Doutorado em Engenharia de Recursos Naturais da Amazônia) - Instituto de Tecnologia, Universidade Federal do Pará, Belém, 2025. Disponível em:https://repositorio.ufpa.br/handle/2011/17876 . Acesso em:.https://repositorio.ufpa.br/handle/2011/17876Acmella oleracea is a medicinal plant from the Amazon, popularly known as jambu. It was used in this thesis as a raw material for the development of a product for oral health that has not been widely reported in the literature and in scientific and intellectual property publications. The liquid pharmaceutical form known as mouthwash is a therapeutic method of administration designed to maintain a biofilm compatible with oral health. Extracts rich in spilanthol have antimicrobial, anti-inflammatory and analgesic properties. The thesis highlights the use of a supercritical fluid extraction process to obtain Acmella oleracea extracts with a high degree of purity through an efficient and sustainable production process. In view of this, the present work involves the development of a mouthwash derived from a plant from the Amazon biome as a low-cost therapeutic alternative through the supercritical technology process, presenting a sustainable and effective solution for oral care, standing out for its significant therapeutic advantages already highlighted in the scientific literature, such as antimicrobial, antibiotic and analgesic activities, in relation to products available on the market.ptAcesso AbertoAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Extrato vegetalCO2 supercríticoEspilantolOdontologiaSaúde bucalPlant extractSupercritical CO2EspilantholDentistryOral healthTeseCNPQ::ENGENHARIASENGENHARIA DE PROCESSOSMATERIAIS E PROCESSOS DE FABRICAÇÃOUSO E TRANSFORMAÇÃO DE RECURSOS NATURAIS