2014-11-282014-11-282010-04PERCÁRIO, Sandro. Prevenção do estresse oxidativo na síndrome de isquemia e reperfusão renal em ratos com suplementação nutricional com antioxidantes. Revista de Nutrição, Campinas, v. 23, n. 2, p. 259-267, mar./abr. 2010. Disponível em: <http://www.scielo.br/pdf/rn/v23n2/v23n2a09.pdf>. Acesso em: 27 nov. 2014. <http://dx.doi.org/10.1590/S1415-52732010000200009>.1415-5273https://repositorio.ufpa.br/handle/2011/6125OBJECTIVE: The objective of this study was to verify the potential protective effect of antioxidant vitamin supplementation in a model of renal ischemic-reperfusion injury in rats. METHODS: Twenty-nine Wistar rats were divided into three groups: groups I and II (n=10 each), were submitted to 60 minutes of renal ischemia, followed by 10 minutes of reperfusion; additionally, animals of group II were treated for twelve days with antioxidant vitamins (vitamin C 11.43mg/kg and vitamin E 28.5 mg/kg) before being submitted to ischemia; In group III (n=9), the animals were treated like the other groups but not submitted to ischemic-reperfusion injury and not given antioxidant supplements. Subsequently, blood samples and the kidneys were collected for assessment of malondialdehyde, uric acid and total antioxidant capacity. RESULTS: The malondialdehyde and uric acid of group I was significantly higher than those of group III (p<0.01), which in turn did not differ from group II. The levels of total antioxidant capacity of the animals of group I was lower than those of groups II and III (p<0.01). CONCLUSION: These data confirmed the effective participation of oxidative stress in this model of renal ischemia-reperfusion syndrome in rats and showed that the use of antioxidant supplementation can protect the animals from oxidative changes.porAcesso AbertoIsquemiaAntioxidantesEstresse oxidativoRadicais livresTransplante de rimTraumatismo por reperfusãoVitaminasArtigo de Periódico