2012-12-202012-12-201997-04PICANÇO-DINIZ, D.L.W. et al. Does plasma ANP participate in natriuresis induced by a-MSH? Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 30, n. 4, p. 459-463, abr. 1997. Disponível em: <http://www.scielo.br/pdf/bjmbr/v30n4/2786C.pdf>. Acesso em: 11 dez. 2012. <http://dx.doi.org/10.1590/S0100-879X1997000400005>.1414-431Xhttps://repositorio.ufpa.br/handle/2011/3290-Melanocyte-stimulating hormone (-MSH; 0.6 and 3 nmol) microinjected into the anteroventral region of the third ventricle (AV3V) induced a significant increase in diuresis without modifying natriuresis or kaliuresis. Intraperitoneal (ip) injection of -MSH (3 and 9.6 nmol) induced a significant increase in urinary sodium, potassium and water excretion. Intraperitoneal (3 and 4.8 nmol) or iv (3 and 9.6 nmol) administration of -MSH did not induce any significant changes in plasma atrial natriuretic peptide (ANP), suggesting that the natriuresis, kaliuresis and diuresis induced by the systemic action of -MSH can be dissociated from the increase in plasma ANP. These preliminary results suggest that -MSH may be involved in a -MSHindependent mechanism of regulation of hydromineral metabolism.engAcesso AbertoHormônio estimulador de melanócitoFator natriurético atrialNatriureseCaliuresesDiurelisArtigo de Periódico