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Type: Artigo de Periódico
Issue Date: Apr-2015
Authors: SÁ, Keyla Santos Guedes de
PIRES NETO, Orlando de Souza
SANTANA, Barbara Brasil
GOMES, Samara Tatielle Monteiro
AMORAS, Ednelza da Silva Graça
CONDE, Simone Regina Souza da Silva
AZEVEDO, Vânia Nakauth
MACHADO, Luiz Fernando Almeida
FEITOSA, Rosimar Neris Martins
ISHAK, Marluísa de Oliveira Guimarães
ISHAK, Ricardo
VALLINOTO, Antonio Carlos Rosário
Title: Toll-like receptor 3 gene polymorphisms are not associated with the risk of hepatitis B and hepatitis C virus infection
Citation: SÁ, Keyla Santos Guedes de et al. Toll-like receptor 3 gene polymorphisms are not associated with the risk of hepatitis B and hepatitis C virus infection. Revista da Sociedade Brasileira de Medicina Tropical, Uberaba, v. 48, n. 2, p. 136-142, mar./abr. 2015. Disponível em: <>. Acesso em:.
Abstract: Introduction: The present study investigated the prevalence of two single-nucleotide polymorphisms (SNPs) in the Toll-like receptor 3 (TLR3) gene in patients infected with hepatitis B virus (HBV) and hepatitis C virus (HCV). Methods: Samples collected from HCV (n = 74) and HBV (n = 35) carriers were subjected to quantitative real-time PCR (qPCR) to detect the presence of the SNPs rs5743305 and rs3775291 in TLR3 and to measure the following biomarkers: alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and prothrombin time (PT). A healthy control group was investigated and consisted of 299 HCV- and HBV-seronegative individuals. Results: No signifi cant differences in allele, genotype and haplotype frequencies were observed between the investigated groups, and no association was observed between the polymorphisms and histopathological results. Nevertheless, genotypes TA/AA (rs5743305) and GG (rs3775291) appear to be associated with higher levels of ALT (p<0.01), AST (p<0.05) and PT (p<0.05). In addition, genotypes TT (rs5743305; p<0.05) and GG (rs3775291; p<0.05) were associated with higher GGT levels. Conclusions: This genetic analysis revealed the absence of an association between the polymorphisms investigated and susceptibility to HBV and HCV infection; however, these polymorphisms might be associated with a greater degree of biliary damage during the course of HCV infection.
Keywords: Prevalência
Polimofismo de nucleotídeo
Hepatite B
Hepatite C
Infecção por HCV
metadata.dc.relation.ispartof: Revista da Sociedade Brasileira de Medicina Tropical
ISSN: 0037-8682
Country: Brasil
Publisher: Universidade Federal do Pará
Institution Acronym: UFPA
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICB

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