Please use this identifier to cite or link to this item: http://repositorio.ufpa.br:8080/jspui/handle/2011/10808
Title: Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats
metadata.dc.creator: BRITO, Marcus Vinicius Henriques
YASOJIMA, Edson Yuzur
PÉRCARIO, Sandro
RIBEIRO JUNIOR, Rubens Fernando Gonçalves
CAVALCANTE, Lainy Carollyne da Costa
MONTEIRO, Andrew Moraes
COUTEIRO, Rodrigo Paracampo
RODRIGUES, Ivone Aline da Silva
SANTOS, Hellen Aparecida Geyer dos
Keywords: Ischemia
Reperfusion
Saline solution
Hypertonic
Kidney
Rats
Issue Date: Mar-2017
Publisher: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Citation: BRITO, Marcus Vinicius Henriques et al. Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats. Acta Cirúrgica Brasileira, São Paulo, v. 32, n. 3, p. 211-218, Mar. 2017. DOI: http://dx.doi.org/10.1590/s0102-865020170030000005. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/10808. Acesso em:.
Abstract: To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in renal ischemia/reperfusion injury in rats. Methods: Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments. After reperfusion, blood samples were collected for BUN and creatinine serum levels analyzes. TBARS were evaluated in plasma and renal tissue to assess oxidative stress. Kidney histopathological examination were performed. Results: Per+HSS group showed a lower degree of renal dysfunction in relation to I/R group, whereas the technique of remote ischemic perconditioning isolated or associated with saline solution significantly reduced oxidative stress and histological damage. Conclusion:Remote ischemic perconditioning associated or not to saline solution promoted reduction of acute renal injury induced by ischemia/reperfusion.
URI: http://repositorio.ufpa.br/jspui/handle/2011/10808
ISSN: 1678-2674
Appears in Collections:Artigos Científicos - ICB

Files in This Item:
File Description SizeFormat 
Article_EffectsHypertonicSaline.pdf1,25 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons