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Title: Pacientes portadores de diabetes mellitus tipo2 atendidos no Instituto de Previdência e Assistência do município de Belém IPAMB: aspectos epidemiológicos e genéticos
metadata.dc.creator: OLIVEIRA, Bárbara de Alencar
metadata.dc.contributor.advisor1: GUERREIRO, João Farias
Keywords: Diabetes mellitus
Diabetes mellitus tipo 2
Polimorfismo de nucleotídeo simples
Marcadores genéticos do diabetes mellitus
Epidemiologia genética
Issue Date: 18-Jun-2019
Publisher: Universidade Federal do Pará
Citation: OLIVEIRA, Bárbara de Alencar. Pacientes portadores de diabetes mellitus tipo 2 atendidos no Instituto de Previdência e Assistência do município de Belém IPAMB: aspectos epidemiológicos e genéticos. 2019. 114 f. Dissertação (Mestrado em Saúde, Ambiente e Sociedade na Amazônia) - Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, 2019. Disponível em: Acesso em:.
Abstract: Diabetes mellitus has been considered a 21st century epidemic and each year the number of people with the disease increases worldwide. It is a disease caused by modifiable factors such as hypercaloric diet, sedentary lifestyle, and non-modifiable factors such as genetic heritability. The objective of this study was to describe the occurrence of genetic markers associated with type 2 diabetes mellitus in the population of the city of Belém do Pará, Brazil. The specific objectives were: to validate the association between type 2 diabetes mellitus and the genes: KCNJ11 rs5219, TCF7L2 rs7901695, PPARγ rs1801282, ABCA1 rs9282541, FTO rs8050136 and rs9939609; and investigate the association between factors related to the development and evolution of type 2 diabetes mellitus such as: BMI, waist circumference, systemic arterial hypertension, sedentary lifestyle, smoking, alcoholism and metabolic syndrome. A research form was applied and blood was collected for DNA extraction. A case-control study was conducted with 147 individuals. The sample consisted of 54 women and 49 men, totaling 103 individuals with the disease, and the control group with 27 women and 17 men without type 2 diabetes mellitus, pre-diabetes or any other type of diabetes, totaling 44 individuals. The study was carried out at the Belém Municipal Institute of Welfare and Care. Regarding the genes studied, only KCNJ11 rs5219 was statistically significant in women (n = 81, p = 0.025). Considering the factors associated with type 2 diabetes mellitus, only the metabolic syndrome presented statistical significance in both genders (p = 0.01).
Appears in Collections:Dissertações em Saúde, Ambiente e Sociedade na Amazônia (Mestrado) - PPGSAS/ICS

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