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dc.creatorTRÉVIA, Nonata-
dc.creatorALMEIDA, Izabela Negrão Frota de-
dc.creatorOLIVEIRA, Poliana Sampaio-
dc.creatorWARWICK, Laura Vianna-
dc.creatorMARQUES, Viviane-
dc.creatorSANTOS, Denise Cristina dos-
dc.creatorVIEGAS, Maria Luana Carvalho-
dc.creatorDINIZ, Cristovam Wanderley Picanço-
dc.creatorPAULO, Dario Carvalho-
dc.identifier.citationTREVIA, Nonata et al. Enriched environment contributes to recovery of visual acuity and increases perineuronal nets in monocular-deprived animals. Psychology & Neuroscience, Rio de Janeiro, v. 4, n. 1, p. 49-56, jun. 2011. Disponível em: <>. Acesso em: 03 abr. 2012. <>.pt_BR
dc.description.abstractThe aim of the present study was to analyze the influence of enriched environment on the distribution of perineuronal nets (PNNs) using a stereogically based unbiased protocol and visual acuity in adult Swiss albino mice that underwent monocular deprivation during the critical period of postnatal development. Eight female Swiss albino mice were monocular deprived were removed and cut at 70 µm thickness in a vibratome and processed for lectin histochemical staining with Wisteria floribunda agglutinin (WFA). Architectonic limits of area 17 were conspicuously defined by WFA histochemical staining, and the optical fractionator stereological method was applied to estimate the total number of PNNs in the supragranular, granular, and infragranular layers. All groups were compared using Student's t-test at a 95% confidence level. Comparative analysis of the average PNN estimations revealed that the EE group had higher PNNs in the supragranular layer (2726.33 ± 405.416, mean ± standard deviation) compared with the SE group (1543.535 ± 260.686; Student's t-test, p = .0495). No differences were found in the other layers. Visual acuity was significantly lower in the SE group (0.55 cycles/degree) than in the EE group (1.06 cycles/degree). Our results suggest that the integrity of the specialized extracellular matrix PNNs of the supragranular layer may be essential for normal visual acuity development.pt_BR
dc.rightsAcesso Aberto-
dc.subjectAcuidade visual-
dc.subjectCórtex visual-
dc.subjectVisão monocular-
dc.subjectPeríodo crítico (Psicologia)-
dc.titleEnriched environment contributes to recovery of visual acuity and increases perineuronal nets in monocular-deprived animalspt_BR
dc.typeArtigo de Periódico-
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