Please use this identifier to cite or link to this item: http://repositorio.ufpa.br:8080/jspui/handle/2011/3844
Title: Canine visceral leishmaniasis due to Leishmania (L.) infantum chagasi in Amazonian Brazil: comparison of the parasite density from the skin, lymph node and visceral tissues between symptomatic and asymptomatic, seropositive dogs
Other Titles: Leishmaniose visceral canina causada por Leishmania (L.) infantum chagasi na Amazônia brasileira: comparação da densidade parasitária da pele, linfonodo e vísceras entre cães soropositivos, sintomáticos e assintomáticos
metadata.dc.creator: LIMA, Luciana Vieira Rego
CARNEIRO, Liliane Almeida
CAMPOS, Marliane Batista
CHAGAS, Eujênia Janis
LAURENTI, Márcia Dalastra
CORBETT, Carlos Eduardo Pereira
LAINSON, Ralph
SILVEIRA, Fernando Tobias
Keywords: Leishmaniose visceral canina
Leishmania infantum chagasi
Densidade parasitária
Pará - Estado
Amazônia brasileira
Issue Date: Oct-2010
Citation: LIMA, Luciana Vieira R., et al. Canine visceral leishmaniasis due to Leishmania (L.) infantum chagasi in Amazonian Brazil: comparison of the parasite density from the skin, lymph node and visceral tissues between symptomatic and asymptomatic, seropositive dogs. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 52, n. 5, p. 259-265, set./out. 2010. Disponível em: <http://www.scielo.br/pdf/rimtsp/v52n5/a07v52n5.pdf>. Acesso em: 10 maio 2013. <http://dx.doi.org/10.1590/S0036-46652010000500007>.
Abstract: Canine visceral leishmaniasis (CVL) is recognizable by characteristic signs of disease and is highly lethal. The infection, however, may be quite inapparent in some seropositive dogs, and this has raised the polemic question as to whether or not such animals can be a source of infection for Lutzomyia longipalpis, the vector of American visceral leishmaniasis (AVL). In this study we have examined 51 dogs with acute CVL from an AVL area in Pará State, northern Brazil, and compared the parasite density, amastigotes of Leishmania (L.) infantum chagasi, in the skin, lymph node and viscera of symptomatic with that of nine asymptomatic but seropositive dogs (IFAT-IgG). Post-mortem biopsy fragments of these tissues were processed by immunohistochemistry, using a polyclonal antibody against Leishmania sp. The X2 and Mann Whitney tests were used to evaluate the means of infected macrophage density (p < 0.05). There was no difference (p > 0.05) in the skin (10.7/mm2 x 15.5/mm2) and lymph node (6.3/mm2 x 8.3/mm2), between asymptomatic and symptomatic dogs, respectively. It was higher (p < 0.05), however, in the viscera of symptomatic (5.3/mm2) than it was in asymptomatic (1.4/mm2) dogs. These results strongly suggest that asymptomatic or symptomatic L. (L.) i. chagasi-infected dogs can serve as a source of infection, principally considering the highest (p < 0.05) parasite density from skin (10.7/mm2 x 15.5/mm2), the place where the vetor L. longipalpis takes its blood meal, compared with those from lymph node (6.3/mm2 x 8.3/mm2) and viscera (1.4/mm2x 5.3/mm2).
URI: http://repositorio.ufpa.br/jspui/handle/2011/3844
ISSN: 0036-4665
1678-9946
Appears in Collections:Artigos Científicos - NMT

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