Please use this identifier to cite or link to this item: http://repositorio.ufpa.br:8080/jspui/handle/2011/4345
metadata.dc.type: Artigo de Periódico
Issue Date: Jun-2009
metadata.dc.creator: TORRES, Alex José Leite
ANGELO, Ana Luiza Dias
MARTINS NETTO, Eduardo
SAMPAIO, Geraldo Pedral
SOUZA, Denise Ferreira de
INOCÊNCIO, Lílian do Amaral
LEMOS, José Alexandre Rodrigues de
BRITES, Carlos Roberto
Title: Reference range for T lymphocytes populations in blood donors from two different regions in Brazil
Citation: TORRES, A. J. L., et al. Reference range for T lymphocytes populations in blood donors from two different regions in Brazil. Brazilian Journal of Infectious Diseases, Salvador, v. 13, n. 3, p. 221-225, jun. 2009. Disponível em <http://www.scielo.br/pdf/bjid/v13n3/v13n3a13.pdf>. Acesso em: 04 out. 2013. <http://dx.doi.org/10.1590/S1413-86702009000300013>.
Abstract: This study defined the normal variation range for different subsets of T-lymphocyte cells count in two different Brazilian regions. We analysed the T-lymphocytes subpopulations (CD3+, CD4+, CD8+) in blood donors of two Brazilian cities, located in North (Belem, capital state of Para, indian background) and Northeast (Salvador, capital state od Bahia, African background) regions of Brazil. Results were compared according to gender, stress level (sleep time lower than 8 hours/day), smoking, and alcohol intake. Lymphocytes subpopulations were measured by flow cytometry. Five hundred twenty-six blood donors from two Brazilians cities participated in the study: 450 samples from Bahia and 76 samples from Pará. Most (60%) were men, 59% reported alcohol intake, 12% were smokers, and 80% slept at least 8 h/day. Donors from Bahia presented with significantly higher counts for all parameters, compared with Para. Women had higher lymphocytes levels, in both states, but only CD4+ cells count was significantly higher than men's values. Smokers had higher CD4+ counts, but sleep time had effect on lymphocytes levels only for Para's donors (higher CD3+ and CD4+ counts). That state had also, a higher proportion of donors reporting sleep time <8 h/day. The values for CD3, CD4 and CD8+ cells count were significantly higher in blood donors from Bahia than among those from Pará. Female gender, alcohol intake, stress level, and smoking were associated with higher lymphocyte counts. The use of a single reference range for normal lymphocytes count is not appropriate for a country with such diversity, like Brazil is.
Keywords: Linfócitos T CD4 Positivos
Doadores de sangue
Linfócitos T CD8 Positivos
Valor de referência
ISSN: 1413-8670
metadata.dc.rights: Acesso Aberto
Appears in Collections:Artigos Científicos - ICB

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