Epidemiologia molecular dos Vírus linfotrópico de células T humanas 1 e 2 (HTLV-1 e HTLV-2) e do Herpesvírus humano 8 (HHV-8) co-infectando portadores do Vírus da imunodeficiência humana 1 (HIV-1)

Abstract

The HTLV-1/2 belongs to the family Retroviridae, which includes HIV. The HHV-8 belongs to the family Herpesviridae. The HTLV-1/2, HHV-8 and HIV have the same modes of transmission, resulting in common risk factors that can justify the co-infection HIV/HTLV and HIV/HHV-8. The present study had as objective to describe the molecular epidemiology of infections caused by HTLV-1/2 and HHV-8 in individuals with HIV-1 with or without AIDS in Belém, Pará. Of 520 samples included in the study, 515 were tested for the presence of anti-HTLV-1/2 and 499 for the presence of anti-HHV-8 by ELISA. Samples reactive for HTLV, and HHV-8 were subjected to molecular methods. The seroprevalence of co-infection HIV/HTLV was 2.3%, while co-infection HIV/HHV-8 was 35.9%. Nine samples of the HTLV were sequenced and one classified as HTLV-1 belonging to the Cosmopolitan subtype, Transcontinental subgroup, and 3 as HTLV-2 of the subtype HTLV-2c, while the HHV-8 are clustered to subtype B. Was found to heterosexual, less educated and impoverishment among the carrier of the HIV-1 and had not association with risk factors. There was no association of the co-infection HIV/HTLV with the risk factors neither with the count of the CD4+ and CD8+ T cells and viral load of HIV-1 in relation the mono-infected. There is association of co-infection HIV/HHV-8 with viral load of HIV-1. There was a higher rate of plasma viral load of HIV-1 in the interval 1000|—100000 copies / mL in the group of coinfected HIV/HHV-8.